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Tytuł oryginału: Multiple extrarenal complications of Wegener's granulomatosis.
Autorzy: Rihova Zuzana, Merta Miroslav, Rysava Romana, Bezdicek Petr, Danzig Vilem, Gorican Karel, Lukas Jindrich, Skalicka Pavlina, Vernerova Zdenka, Tesar Vladimir
Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.1-4, il., tab., bibliogr. 11 poz.
Sygnatura GBL: 313,612

Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: We describe a sace of Wegener's Granulomatosis (WG), a diseases characterized by necrotizing granulomatous lesions and vasculitis of the upper and lower respiratory tract, necrotizing glomerulonephtitis with crescent formation and systemic vasculitis. Case report: The patients initially presented with a corneal perforation. In addition to the eye involvement, multiple other organ involvement was found during the course of the disease. The renal biopsy showed a pauciimmune necrotizing glomerulonephtitis with occlusive fibrocellular crescents, the interstitium was focally fibrotic with the skin vasculitis and arthralgias. Cardiac involvement included an acute myocardial infaraction and aortic valve vegetation, most likely caused by WG. Another complication during the initial presentation was a massive intestinal bleeding. The diagnosis of WG was established by renal, conjunctival and upper airway biopsies and by positive c-ANCA. The clinical and laborotory remission of the disease was achieved by combined immunosuppressive therapy with cyclophosphamide and corticosteroids. Later in the course of the disease the patient developed a subglottic stenosis, most probably due to reparative changes. Conclusions: In conclusion, this is a case of WG with multiple extrarenal complications, that had a grave clinical course.

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