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Tytuł oryginału: Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia.
Autorzy: Hoelzer Dieter, G”kbuget Nicola, Digel Werner, Faak Thomas, Kneba Michael, Reutzel Regina, Romejko-Jarosińska Joanna, Zwoliński Jacek, Walewski Jan
Źródło: Blood 2002: 99 (12) s.4379-4395, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We treated 45 adult patients with T-lymphoblastic lymphoma (T-LBL) (age range 15-61 years) with 2 protocols designed for adult acute lymphoblastic leukemia (ALL). An encouraging cure rate of 90 p.c. was recently reported for T-LBL in children treated with a similar approach. In our study an 8-drug standard induction was administered over 8 weeks including prophylactic cranial (24 Gy) and mediastinal irradiation(24 Gy) followed by consolidation and reinduction therapy. AT diagnosis, 91 p.c. of the 45 patients showed a mediastinal tumor and 40 p.c. had pleural/pericardial effusions: 73 p.c. of the patients had stage III/IV disease. Ovarall 42 patients (93 p.c.) achieved a complete remission (CR), 2 patients (4 p.c.) achieved a partial remission, and 1 patient (2 p.c.) died during induction. In patients with stage I-III disease (n=18) the CR rate was 100 p.c. compared with 89 p.c. in stage IV (n=27). There were 15 patients who relapsed (36 p.c.) within 12-months. The majority of relapses (47 p.c.) occurred in the mediastinum (n=7) despite mediastinal irradiation with 24 Gy in 6 out of 7 patients. The estimates for overall survival, continuous CR, and disease-free survival at 7 years are 51 p.c., 65 p.c., and 62 p.c., respectively. Stage, age, lactate dehydrogenase and all other parameters had no influence on achievement of CR or outcome. This study demonstrates in a large cohort of patients with adult T-LBL that a high CR rate and a favourable outcome can be achieved with an ALL-type regimen. Mediastinal recurrence was the major obstacle and further improvement...

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