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Zapytanie: REINA-TORAL
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Tytuł oryginału: Alteplase: double bolus versus accelerated regimen.
Autorzy: Ruiz-Bailen Manuel, Hoyos Eduardo Aguayo de, Hurtado-Ruiz Benjamin, Reina-Toral Antonio, Diaz-Castellanos Miguel Angel, Issa-Khozouz Ziad
Źródło: Med. Sci. Monitor 2002: 8 (10) s.PI85-PI92, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The purpose of our study was to compare the efficacy and safety fo alteplase in acute myocardial infarction (AMI), when administered in a double bolus regimen or an accelerated regiment during admission to an intensive care or coronary care unit (ICU/CCU). Material/Methods: A retrospective cohort study including all the AMI patients treated with alteplase recorded in the ARIAM register (Analysis of Delay in AMI), a multi-center register in which 77 Spanish hospitals participate. The study period was from January 1995 to January 2000. Results: 4615 AMI patients were studied. THe accelerated regimen (Group I) was administerd to 57.51 p.c. (2,654 patients) and the remaining 42.49 p.c. (1,961 patients) received the double bolus regimen (Group II). There were no differences in mortality or in teh incidence of hemorhagic strokek between the groups. THe mortality was 7.15 p.c. in Group I versus 6.43 p.c. in Group II (not significant). The incidence of hemorrhagic stroke was 1.o9 p.c. in Group I versus 1.22 p.c. in Group II (not significant). Fewer coronary angiograpies were required in Group I (6.28 p.c. vs. 8.99 p.c.; p 0.001) and fewer rescue angioplasties (10.67 p.c. vs. 21.88 p.c., p = 0.03). Group I also showed a smaller requirement for stent insertion (1.45 p.c. vs e.77 p.c.; p 0.0001) and for assistance using intra-aortic balloon contrapulsation (0.47 p.c. vs. 1.36 p.c.; p = 0.02). Conclusions: The two regimens appear to be similar in efficacy and safety. Nevertheless, from these results it may be hypothesized that further revascularization techniques are required after double bolus administration.

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