Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: The inhibitory effect of the fungicides captan and captafol on eukaryotic topoisomerases in vitro and lack of recombinagenic activity in the wing spot test of Drosophila melanogaster.
Autorzy: Rahden-Staroń Iwonna
Źródło: Mutat. Res 2002: 518 (1/2) s.205-213, il., tab., bibliogr. 53 poz.
Sygnatura GBL: 304,952

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • in vitro

    Streszczenie angielskie: In studies on the mechanisms of mutagenic and carcinogenic action of captan and captafol-related chloroalkylthiocarboximide fungicides, two effects were tested: (i) the effect of both compounds on the activity of eukaryotic topoisomerase I and II in vitro, and (ii) their mutagenic and recombinagenic activity in the somatic mutation and recombination test (SMART) in wing cells of Drosophila melanogaster. Only captofal inhibited the activity of topoisomerase I (10-20 p.c. inhibition of activity in the range of 10-100 ćM). In contrast, both chemical decreased the activity of topoisomerase II already at 1 ćM concentration (50 and 20 p.c. inhibition of activity by captafol and captan, respectively). Genotoxicity was tested in vivo by administrating both compounds by acute (3 h) and chronic feeding (48 h) of 3-day-old exposure concentration range. Both chemical were inconclusive for large single spots, as well as for twin spots. In chronic treatment, captan showed positive results only for small single and total spots at 2.5 and 5 mM concentrations. Captafol gave inconclusive results over all concentrations tested. The results of the acute treatment experiments which have been performed at very high doses (50 p.c. toxicity at higher doses) indicate very weak overall mutagenic activity of both test fungicides.


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    Tytuł oryginału: Biochemia : skrypt do ćwiczeń laboratoryjnych dla studentów I Wydziału Lekarskiego
    Autorzy: Szumiło Maria, Czeczot Hanna, Graboń Wojciech, Sadurska Bożenna, Barańczyk-Kuźma Anna, Rahden-Staroń Iwonna
    Opracowanie edytorskie: Barańczyk-Kuźma Anna (red.).; Akademia Medyczna Katedra i Zakład Biochemii w Warszawie
    Źródło: - Warszawa, Wydaw. AM 2002, [10], 130 s. : il., powiel., 21 cm.
    Sygnatura GBL: 736,037

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