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Tytuł oryginału: Integrated indexes of occupational exposure as predictors of kidney dysfunction.
Autorzy: Jakubowski Marek, Trzcinka-Ochocka Małgorzata, Hałatek Tadeusz, Raźniewska Grażyna, Szymczak Wiesław
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.393-399, il., tab., bibliogr. 20 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:
  • nefrologia
  • medycyna pracy
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to evaluate the dose-effect and dose-response relationships between the integrated indexes Cd-A ú t (mg/m**3 ú years of exposure) and Cd-B ú years of exposure), and the increase in retinol binding protein excretion in urine (RBP-U) and á2-microglobulin concentration in serum (á2M-S). The study was carried out in the nickel-cadmium battery factory in 1998-1999. Exposure to cadmium was formerly very high. The study group consisted of 116 persons for whom the results of determinations of Cd-B were available during two former observation periods (1983 and 1986-1988). The mean age of the gorup was 49 years and the mean period of exposure was 17 years. The dose-effect relationship between Cd-B ú t and RBP-U or á2M-S was much better (r = 0.642 and 0.513) than between Cd-A út and RBP-U or á2M-S (r = 0.173 and 0.127). There was also correlation between Cd-U (ćg/g creatinine), measured in 1998-1999, and RBP-U or á2M-S (r = 0.343 and 0.198). Urinary cadmium should, however, be used with caution as a dose estimate because its excretion may increase as a result of renal damage. According to the dose-response relationship, an increase in RBP excretion above 300 ćg/g creatinine can be expected in 10 p.c. of subjects at the integrated exposure index (Cd-B ú t) of about 450 ćg/l ú years, and an increase in á2M-S above the accepted cut-off point of 2.4 mg/l can be expected in 10 p.c. of subjects at Cd-B ú t of about 190 ćg/l ú years. The data obtained confirmed the validity of the recommended at present health-based limit for occupational exposure of 5 ćg/l of blood, as well as the superiority of the biological monitoring of exposure to cadmium over the environmental monitoring.

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