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Tytuł oryginału: Integrin pattern in rats endometrium after endometriosis excision.
Autorzy: Szymanowski K., Mikołajczyk M., Rączyńska P., Florek E., Skrzypczak J.
Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.299-302, bibliogr. 8 poz.
Sygnatura GBL: 313,538

Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Search for a reliable endometriosis marker still continues. In this study an analysis was performed of the ŕ3á1, ŕ4á1 integrins and á1 integrin subunit in the endometrial glandular epithelium in 28 rats, before peritoneal endometriosis induction, 3 months after induction and 3 months after endometriosis excision. Peritoneal endometriosis induction caused characteristic changes in integrin pattern in uterine glandular epithelium. Of all investigated integrins no one could be detected in glandular epithelium. After endometriosis induction, which succeeded in 21 animals ŕ3á1, ŕ4á1 subunit could be found in endometrial glandular epithelium of 16,18 and 18 animals, respectively. Three months after endometriosis excision these integrins were still present in endometrial epithelium of 6, 5 and 8 rats of the above groups, respectively. The endometrial sampling did not reveal complete return of the integrin pattern in glandular to the pattern observed before endometriosis induction. The question remains whether ŕ3á1, ŕ4á1 and á1 chain has not a fully satisfactory prognostic value in endometriosis diagnosis or did the inflammatory process associated with tissue healing influence integrin pattern.

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