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Tytuł oryginału: Distribution of dermally absorbed 14C DDT in the organs of wistar rats.
Autorzy: Toś-Luty Sabina, Tokarska-Rodak Małgorzata, Latuszyńska Jadwiga, Przebirowska Daniela
Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.215-223, il., tab., bibliogr. 21 poz.
Sygnatura GBL: 313,158

Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of study was evaluation of the concentration of dermally applied 14C DDT in the organs of rats, and evaluation of histological and ultrastructural changes after the dermal application of unlabelled DDT standard in the organs of rats, in which the presence of this pesticide was determined by the radio-isotopic method. 14C DDT of radiochemical purity of 97 p.c. was applied in the study. The activity of the preparation per 1 cmý of the tail skin was 22.2 kB2 -n (175.38 ćg DDT). The material for the study was taken directly after single exposure and 6 h, 8 h, 10 h, 12 h, 14 h, 18 h and 20 h after exposure. The following organs were taken for the determination of radioactivity of tissues: brain, heart, lung, liver, kidney, skin at the site of exposure. Unlabelled chemically pure, DDT (99.7 p.c.) was used to evaluate histological and ultrastructural changes after dermal application. Experimental animals received an oil emulsion of DDT (10 mg/9 cmý), applied to the skin of the tail for 4 weeks. The time of exposure was 4 h daily. The animals of the control group were dermally exposed to the emulsion at the same time and under the same conditions. 4 h after dermal exposure it was observed that the preparaation applied on the surface of 9 cmý in the amount of 1.578 ćg was present in the skin in the amount of 1 ćg/9 cmý (0.11 ćg/cmý), i.e. 0.063 p.c. of 14C DDT applied dose. Directly after dermal application lasting 4 h the greatest amount of 14C DDT was noted in the liver - 0.285 ćg, i.e. 0.033 ćg/g. Histopatological and ultrastructural changes were observed in the liver, kidney, lungs and heart.

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