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Tytuł oryginału: Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice.
Autorzy: Świąder Mariusz, Borowicz Kinga K., Porębiak Jacek, Kleinrok Zdzisław, Czuczwar Stanisław J.
Źródło: Eur. Neuropsychopharmacol. 2002: 12 (4) s.311-319, il., tab., bibliogr. s. 317-319
Sygnatura GBL: 313,361

Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: It was previously documented that calcium (Caý+) channel inhibitors intensified the protective effects of conventional antiepileptics against electroconvulsions in mice. The aim of this study was to evaluate the effects of Caý+ channel inhibitors (nifedipine, nicardipine and fluarizine) on the anticonvulsant action of the new AMPA/kainate receptor antagonist, 7-acetyl-3-94-aminophenyl)-8,9-dihydro-8-methyl-7H--1,3-dioxazolo[4,5-h][2,3]-benzodiazepine (LY 300164), against maximal electroshock (MES)-induced seizures in mice. Dantrolene (an inhibitor of Caý+ release from intracellular stroes) was also included. Nifedipine (30 mg/kg) and flunarizine (15 mg/kg) raised the threshold for electroconvulsions, being ineffective at lower dose. Nicardipine (up to 30 mg/kg) and dantrolene (up to 20 mg/kg) did not affect this parameter. Flunarizine (10 mg/kg), nicardipine (20 mg/kg) and dantrolene (20 mg/kg) potentiated the efficacy of LY 300164 against MES. However, nicardipine (at 20 mg/kg) raised the free plasma concentraion of LY 300164. Nifedipine (30 mg/kg), given even in a dose raising the electroconvulsive threshold, did not significantly alter the protective effect of LY 300164 against MES. Furthermore, the Caý+ channel agonist - BY k-8644 (at mg/kg) did not influence the protection offered by LY 300164 against MES. Finally, this Caý+ channel activator did not affect the enhanced efficacy of LY 300164 by Caý+ channel modulators. The only exception was the combination of LY 300164 with flunarizine. Combined treatment with LY 300164 and dantrolene (20 mg/kg)...

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