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Low-dose ritonavir moderately enhances nelfinavir exposure.
Clin. Pharmacol. Ther. 2002: 72 (2) s.123-132, il., tab., bibliogr. 37 poz.
Hasła klasyfikacyjne GBL:
praca opublikowana za granicą
dorośli 19-44 r.ż.
Bacground: The protease inhibitor ritonavir is increasingly administered at subtherapeutic doses in highly acyive antiretroviral treatment, to utilize its potential for drug interactions and to enhance the plasma concentrations of other concomitantly prescribed protease inhibitors. The addition of low doses of ritonavir to nelfinvir as investigated to describe the extent of pharmacokinetic interaction. Methods: In this randomized, open-label, one-sequence crossover study, nelfinavir 1250 mg a day was dosed for 17 days, followed by 14 days of nelfinvar 1250 mg twice a day plus low doses of ritonavir of either 100 mg or 200 mg orally. Twenty-four healthy volunteers were evaluated for pharmacokinetics of nelfinavir, its metabolite M8, and ritonavir. Plasma concentrations were measured up 12 hours after moring and evening dosing, respectively, on days 14 and 31. Results: Ritonavir increased the area under the plasma concentration-time curve (AUC) of nelfinvir by 20 p.c. (P = .024) and 39 p.c. (P = .001) after moring and evening administration, respectively. The AUC of nelfinavir metabolite M8 was increased by 74 p.c. and 86 p.c. after moring and evening dosing (P .001 for both). Conclusion: During ritonavir combination therapy a clear although minor drug effect on nelfinavir pharmacokinetics was demonstrated but no dose effect was shown.
The contribution of non-invasive imaging modalities to the diagnosis of left ventricular pseudoaneurysm.
Udział nieinwazyjnych metod obrazowania w diagnostyce tętniaka rzekomego lewej komory.
Prz. Lek. 2002: 59 (8) s.642-645, il., bibliogr. 14 poz.
Hasła klasyfikacyjne GBL:
Background: Left ventricular pseudoaneurysm (LVPA) is a rare entity characterized by a tendency to spontaneous rupture due to its morphology, a lack to myocardial fibers and fibrous tissue delineating the cavity. An early diagnosis is essential in order to guide appropriate therapy. Purpose: To determine the diagnostic accuracy of different imaging techniques, treatment results, and prognosis of patients (pts) with LVPA. Methods: We evaluated the incidence of LVPA during a five-year period. The initial clinical presentation, the etiology of LVPA, time between symptom onset and diagnosis, and use of various non-invasive techniques were studied. Mean follow-up was 15 months. Results: Of 19113 pts admitted to our Institute in a five-year period, LVPA was diagnosed in 11 pts (o.or p.c.) (mean age 51 ń 3.9 years, 8 men). The diagnosis of LVPA was confirmed by surgery in 4 pts, and by pathology in 2 pts. LVPA was and incidental finding in one asymptomatic pt, it was diagnosed in 6 pts presenting with an acute myocardial infarction (AMI) and in 4 pts presenting with LV failure. The main etiology was coronary artery disease (CAD) (9 pts), with the remaining 2 cases being post-traumatic (thoracic stab wound, surgery). LVPA location was postero-inferior in 6 patients infero-lateral in 3 patients, and anterior in 2 patients. ECG, X-ray and TTE were performed in all cases. 6 pts had a radionuclide angiography (RNA), 3 pts had a computed tomography (CT) scan and 2 pts had a magnetic resonance imaging (MRI) study. Two-dimensional transthoracic echocardiography (TTE) provided information regarding LVPA...
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