Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
POLESZAK
Liczba odnalezionych rekordów:
3
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Tytuł oryginału:
Adenosine receptor ligands and cocaine in conditioned place preference (CPP) test in rats.
Autorzy:
Poleszak
Ewa,
Malec
Danuta
Źródło:
Pol. J. Pharmacol. 2002: 54 (2) s.119-126, il., bibliogr. 38 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
nefrologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
Streszczenie angielskie:
The influence of adenosine receptor agonists and antagonists on cocaine-induced conditioned place preference (CPP) was examined in male Wistar rats. Adenosine receptor agonists, when given alone, induced place preference in some dose ranges, and it seems that adenosine A1 and A2 receptors might be involved in this reaction. All adenosine receptor agonists: 2-p-(2-corboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680), A2A receptor agonist, N6-cyclopentyladenosione (CPA), A1 receptor agonist, and 5'-N-ethylcarboxamidoadenosine (NECA), A2/A1 receptor agonist did not prevent the acquisition of cocaine-induced CPP but, when administered at the lower doses, they reduced the expression of cocaine action in CPP test. Selective adenosine A1 receptor antagonist, 8-cyclopentyltheophylline (CPT), A2 receptor antagonists, 3,7-dimethyl-1-propargylxanthine, DMPX, and caffeine (non-selective A1/A2 receptor antagonist) markedly and significantly decreased the expression of CPP induced by cocaine, and caffeine (20 mg/kg) decreased also the acquisition of this reaction. Our results suggest the involvement of adenosine A1 and A2 receptors in rewarding prperties of cocaine measured in CPP test.
2/3
Tytuł oryginału:
Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.
Autorzy:
Poleszak
Ewa,
Malec
Danuta
Źródło:
Pol. J. Pharmacol. 2002: 54 (4) s.359-366, il., bibliogr. 43 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
myszy
płeć męska
Streszczenie angielskie:
The influence of adenosine receptor agonists and antagonists on cocaine and amphetamine-induced hyperactivity was examined in mice. All adenosine receptor agonists significantly decreased the locomotor activity in mice, and the effects were dose-dependent. It seems that adenosine A1 and A2 receptors might be involved in this reaction. Moreover, all adenosine receptor agonists: 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680), A2A receptor agonist, N6-cyclopentyladenosine (CPA), A1 receptor agonist, and 5'-N-ethylcarboxamidoadenosine (NECA), A2/A1 receptor agonist significantly and dose-dependently decreased cocaine-induced locomotor activity. CPA reduced cocaine action at the doses which, given alone, did not influence motility, while CGS 21680 and NECA decreased the action of cocaine at the doses which, given alone, decreased locomotor activity in animals. These results suggest the involvement of both adenosine receptors in the action of cocaine although agonists of A1 receptors seem to have stronger influence on it. The selective blockade of A2 adenosine receptor by DMPX (3,7-dimethyl-1-propargylxanthine) significantly enhanced cocaine-induced locomotor activity of animals. Caffeine had similar action but the effect was not significant. CPT (8-cyclopentyltheophylline) - A1 receptor antagonist, did not show any influence in this test. Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity. The selective blockade of A2....
3/3
Tytuł oryginału:
Wpływ agonistów i antagonistów receptorów adenozynowych na morfinową preferencję miejsca u szczurów.
Tytuł angielski:
The influence of adenosine receptors ligands on morphine-induced place preference in rats.
Autorzy:
Listos
Joanna,
Poleszak
Ewa,
Malec
Danuta
Źródło:
Ann. UMCS, Sect. DDD 2002: 15 s.185-200, il., bibliogr. 33 poz., sum.
Sygnatura GBL:
312,920
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
Wskaźnik treści:
zwierzęta
szczury
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