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Kwasy tłuszczowe błon komórkowych bakterii jako wskaźniki toksyczności związków aromatycznych.
Fatty acids of bacterial membranes as a biomarker of aromatic compounds toxicity.
Post. Mikrobiol. 2002: 41 (2) s.185-197, il., tab., bibliogr. 60 poz., sum.
Hasła klasyfikacyjne GBL:
In all bacteria fatty acids are found as a major component of their membrane lipids. The well-known spectrum of bacterial fatty acids comprises saturated, cis, trans-monounsaturated, diunsaturated, cyclopropane, hydroxyl and methyl-branched fatty acids. Recently a new type has been found as membrane constituents - polyunsaturated fatty acids. The physical properties of bacterial membranes are determined by the composition of fatty acids. Some membrane active agents, including aromatic compounds, have a strong influence on membrane fluidity. These compounds dissolve in the cell membrane disturbing its integrity and affecting specific permeabilization. The hydrophobicity of an aromatic compound, expressed as its logP value, is a good indicator of its toxicity. Microorganisms however can adapt to many organic compounds by changing of their membrane fluidity. They can modify degree of saturation of fatty acids, the average chain length and the protein content. This mechanism is called "homeoviscosis adapatation". One of the key processes in the adaptation of some Pseudomonas, Vibrio and Escherichia coli strains, enabling them to tolerate aromatic compounds, appears to be the isomerization of cis - into trans-unsaturated fatty acids. The analysis of microbial membrane lipids, specifically phospholipid fatty acids (PLFA) is a powerful tool for monitoring the microbial responses to changes in tehir environment. Phospholipids are extracted directly from environmental samples to characterise microorganisms within their communities...
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