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PIETSZ
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Tytuł oryginału:
Synthesis and tumoricidal activity evaluation of new morin and quercetin sulfonic derivatives.
Autorzy:
Król
Wojciech,
Dworniczak
Szymon,
Pietsz
Grażyna,
Czuba
Zenon P.,
Kunicka
Mariola,
Kopacz
Maria,
Nowak
Dorota
Źródło:
Acta Pol. Pharm. 2002: 59 (1) s.77-79, il., tab., bibliogr. 21 poz.
Sygnatura GBL:
301,378
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
myszy
szczury
in vitro
Streszczenie angielskie:
Flavonoids are a group of naturally occuring compounds with interesting medical properties, such as antiinflammatory, antiallergic, antibacterial and antitumor activities. In our experiments we were trying to examine the tumoricidal activity of newely synthesized derivatives of two flavonoids: 3,5,7,2',4' - pentahydroxyflavone (morin) and 3,5,7,3',4' - pentahydroxyflavone (quercetin). The derivatives were: natrium salt of morin-5'-sulfonic acid (NaMSA), natrium salt of quercetin-5'-sulfonic acid (NaQSA), complex of Mg2+ with quercetin-5'-sulfonic acid (QSA), complex of iron (II) with QSA. The antitumor activity of these agents was tested in vitro on two cell lines: L1210 - murine lymphocytic leukaemia and P-815 - murine mastocytoma. Our experiments showed that sulfonic derivatives of these two flavonoids were less potent than the original agents in their cytostatic and cytotoxic activities. However, their solubility in water was grweater than that of the original agents and higher cilture medium concentration of these derivatives was obtained. The results indicate that the ability of flavonoids to act tumoricidally is reciprocally correlated with their lipophilicity.
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