Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PFEIFFER
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication.
Autorzy: Schiemann Uwe, Konturek Jan W., Assert Roland, Rembiasz Kazimierz, Konturek Stanisław J., Pfeiffer Andreas
Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR53-CR58, il., tab., bibliogr. 34 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Epidermal growth factor (EGF) receptor ligands (EGFRL) including transforming growth factor alpha (TGF-ŕ), amphiregulin, and heparin binding -EGF (HB-EGF) are involved in gastric mucosal repair in chronic gastritis. Their mRNA expression has been shown to be upregulated after Helicobacter pylori (H. p.)-eradication but little is known about this gene expression in atrophic gastritis. The purpose of our study was to investigate EGFRL mRNA expression in gastric mucosa of patients with atrophic gastritis before and after H. p.-eradication. Material/Methods: Antral mucosal biopsies were obtained during endoscopy in 10 H. p. positive patients with atrophic gastritis and in 10 H. p. negative controls with intact mucosa. Total RNA of antral biopsies was extracted and RT-PCR was performed, the PCR-products being measured densitometrically. Values were compared with mRNA expressions in H. p. negative antral mucosa (n = 10). Results: Gastric biopsies revealed mRNA expression for TGF-ŕ, amphiregulin and HB-EGF, both in H. p. positive atrophic antritis and in H. p. negative healthy mucosa. The mRNA expression of TGF-ŕ in atrophic gastritis was significantly upregulated after H. p.-eradication, whereas that of amphiregulin did not change after this eradication. Expression of HB-EGF mRNA was higher in H.p.-infection than after H.p.-eradication or in H.p. negative healthy subjects. Conclusions: H.p. positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands. H.p.-eradication in this entity leads to unequal changes of these growth factor expressions compared to chronic active gastritis without atrophy.

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    Tytuł oryginału: Wszczepienie sztucznej soczewki do rowka rzęskowego z fiksacją śródtwardówkową.
    Tytuł angielski: Intraocular lens implantation to the ciliary sulcus with scleral fixation.
    Autorzy: Pfeiffer Grzegorz, Cieślińska Katarzyna, Pecold Krystyna
    Źródło: Okulistyka 2002: 5 (4) s.64-67, tab., bibliogr. 15 poz., sum.
    Sygnatura GBL: 313,465

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Aim: assessment of the condition of the eyes after surgical treatment including implantation of the posterior artificial lens to the ciliary sulcus with sleral fixation. Patients: 26 patients (27 eyes) at the age of 4-85 years, who underwent surgical treatment in the period from 01.1997 to 04.2000. There were 23 men and 2 women. The follow-up time ranged from 7 to 33 months. Results: Improvement of the best-corrected visual acuity after surgery was obtained in 89 p.c. of eyes, in 59,3 p.c. it was value =5/10. Among intraoperative complications the most often was bleeding to the anterior segment of the eye (11 p.c.), in the late postoperative period it was pupil deformation. Conclusions: in the eyes, in which there are no conditions to implant the artificial lens into the capsular bag, the method used above is most profitable, because the localization of the artificial lens approximates most its anatomical position, there are relative low rate of complications and good functional results.

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