Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PETROVIĆ
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Tytuł oryginału: Gene polymorphisms of the renin-angiotensin-aldosterone system and essential arterial hypertension in childhood.
Autorzy: Petrović Danijel, Bidovec Matja, Peterlin Borut
Źródło: Folia Biol. 2002: 50 (1/2) s.53-56, tab., bibliogr. s. 56
Sygnatura GBL: 302,991

Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: In order to investigate the contribution of candidate genes in the renin-angiotensin-aldosterone system (RAAS) in pathogenesis of essential arterial hypertension (EAH), the I/D polymorphism of ACE gene, the M235T polymorphism of the angiotensinogen gene, and the angiotensin II type 1 receptor (AGT1R) A1166C gene polymorphism in a group of children with EAH were analyzed. Fifty-seven children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared with 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure measurments higher than 95 age-gender-height percentile of the adopted reference values. A trend was found towards an association between the M235T angiotensinogen gene polymorphism and EAH in childgood in a dominant model (odds ratio (OR) 2.1; 95 p.c. confidence interval (CI) 0.9 - 5.1; P = 0.077), whereas the authors failed to demonstrate an association between the ACE I/D gene polymorphism, or the A1166C AGT1R gene polymorphism and EAH in childhood. Additionally, evidence was found of interaction between the angiotensinogen-TT genotype and obesity on the risk of EAH in childhood (OR 19.3; 95 p.c. CI 1.1 - 77.3; P = 0.014). In conclusion, the M235T angiotensinogen gene polymorphism is considered alone as well as in interaction with obesity to be risk factors for EAH in childhood.

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    Tytuł oryginału: The relationship between gallbladder motility and the presence of enterogastric reflux.
    Autorzy: Artiko Vera M., Chebib Hamzeh, Petrović Nebojśa, Petrović Milorad, Peśko Predrag, Ussov Wladimir Y., Obradović Vladimir
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.25-28, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of the study was an estimation of the relation between the gallbladder (GB) motility function and the presence and quantity of enterogastric reflux (EGR). Material and methods: We investigated 172 patients: 90 with physiological GB function (filling and emptying) (FGB), 21 with impaired GB function (prolonged filling and ejection fraction 45 p.c.) and 61 with afunctional gallbladder (AGB) (without visualisation). The study was performed during 90 min (1 f/min) after i.v. application of 185 MBq 99m Tc-dietil IDA. After 30 min, a test meal was given while at the end the stomach was marked. According to the parameters from time activity curves over the stomach and hepatobiliary system, the index of EGR was calculated, while GB filling and ejection fraction were estimated from the GB time/activity curve. Results: Most frequently, EGR occurs in AGB (47.5 p.c.), followed by IGB (43 p.c.) and FGB (41 p.c.), without signficiant differences (p 0.05). The signficiantly (p 0.05) highest value of EGR was obtained in the patients with AGB in comparison to IGB and FGB. EGR values were in correlation (r = 0.168, p 0.05) with the functional status of the GB. In the patients with pathological values fo EGR ( 10 p.c.), significantly higher values (p 0.05) are obtained in AGB than in IGB and FGB. Also, these values were in correlation with the functional status of the GB (r - 0.284, p 0.05). Conclusions: We can conclude that EGR occurs more frequently in the patients with afunctional GB in comparison with those with functional and decreased motor function. Also, EGR quantity is in correlation with the impairment of the GB function.

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