Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Human cytomegalovirus infection and abortion: an immunohistochemical study.
Autorzy: Spano Liliana Cruz, Pereira Fausto Edmundo Lima, Basso Nadia Gomes da Silva, Mercon-de-Vargas Paulo Roberto
Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR230-BR235, il., tab., bibliogr. 50 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cytomegalovirus (HCMV) has been described in abortion tissues, but seldom associated with inclusion bodies. However, the possible pathogenic role of this virus in aborton is under discussion. We attempted to verify the realtionship between HCMV antigens in tissues from first trimester abortions presenting with inflammatory lesions. Sixteen cases of first trimester abortions with inflammatory lesions were selected from 340 cases studied at the Pathology Unit of the University Hostoptal in Vitória, Espirito Santo State, Brazil. Paraffin-embedded sections were subjected to indirect immunofluorescence (IFI) and immunoperoxidase (PAP), using monoclonal antibodies directed against immediate early (IEA) and late antigens (LA) of HCMV. Twelve out of sixteen cases (75 p.c.) presented at least one HCMV antigen. Eight cases presented both antigens, three cases only the IEA and one case only the LA. These antigens were present in decidual cells, in stromal cells of chorionic villi and in trophoblastic cells. The results showed high frequency of HCMV antigens in tissues from first trimester abortion. This frequency, higher than that previously reported, was probably due to the fact that necroinflammatory lesions were always present in selected cases. The presence of LA in trophoblastic cells is evnce for cell permissiveness to viral replication in vivo. The results showing high presence of HCMV antigens in tissues from abortion with inflammatory lesions suggest a possible relationship of HCMV infection with inflammation and pregnancy loss.

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    Tytuł oryginału: Dyspnea scales as a measure of health-related quality of life in patients with idiopathic pulmonary fibrosis.
    Autorzy: Martinez Jose Antonio Baddini, Martinez Tieko Yamamoto, Galhardo Fabiola Paula Lovetro, Pereira Carlos Alberto de Castro
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR405-CR410, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease and is usually associated with a poor prognosis. IPF patients have a significant impairment in health-related quality of life (HRQL), both in terms of physical and psychological functioning. A substantial number of dyspnea scales are available to clinicians for clinical and research use. The objective of the present study was to investigate how some commonly used dyspnea scales correlate with measurements of HRQL in IPF patients. A group of 30 patients with IPF who attended a specialized outpatient respiratory clinic were interviewed during a stable period of the disease. HRQL was assessed by the SF-36 questionnaire. Dyspnea was measured by the baseline dyspnea index (BDI), Modified Medical Research Council Scale (MRC), Oxygen Cost Diagram (OCD), clinical element of the Clinical, Roengenographic and Physiologica score (CRP), and a new dyspnea scale (NS) based on estimates of required oxygen consumption for usual activities. Patients showed impariments in all HRQL domains except the Pain Index. All dyspnea scales showed significant correlations with both physical and mental HRQL domains. The highest Spearman's coefficients between dyspnea ratings and SF-36 components were obtained using the BDI. Dyspnea ratings correlate with HRQL measurements in IPF patients. Dyspnea scales can be used as a measure of HRQL in special circumstances.

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