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Tytuł oryginału: Comparison of 99mTC-alafosfalin and 67Ga-citrate in a mouse model of bacterial infection.
Autorzy: Tsopelas Chris, Penglis Stan, Bartholomeusz F. Dylan L.
Źródło: Nucl. Med. Rev. 2002: 5 (2) s.93-97, il., tab., bibliogr. 18 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Background: The antibiotic-peptide 99mTC-alafosfalin was assessed as an infection imaging agent in Staphylococcus aureas infected mice by comparison with 99mGa-citrate, and also examined for influence of septic status on tracer biodistribution by comparison with normal mice. Material and methods: Intramuscular doses of S. aureus were administered into the right thigh muscle of mice and the infection was allowed to develop for 20 hours. In separate experiments, 99mTC-alafosfalin and 67Ga-citrate were subsequently administered adn allowed to localise. Quantitative organ distribution sstudies were performed in conjunction with scintigrapic images at 1 and 4 hours posst injection. An additional biodistribution with 99mTC-alafosfalin in normal mice was also performed. Results: 99mTC-alafosfalin was predominantly renal excreted, with low liver, intestine and bone uptake. Tehre was no difference in the uptake of these organs when infected mice were compared with normal mice. 99mTC-alafosfalin activity in the intestine at 1 and 4 hours was substantially less than 67Ga-citrate. For 99mTC-alafosfalin, infected/non-infected thigh ratios of 2.8/1.0 and 3.6/1.0 were determined at 1 and 4 hours post injection resepectively. 67Ga-citrate gave ratios of 1.6/11.0 and 3.7/1.0 at teh corresponding time points. Conclusions: 99mTC-alafosfalin uptake was mnore rapid than 67Ga-citrate, yet diffuse at the infectious sites in mice. The small and juvenile mouse model resulted in uptake of the phosphonic acid tracer by active ...

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