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Tytuł oryginału: Formation of DNA adducts and environmental exposures to airborne carcinogens.
Autorzy: Peluso Marco, Munnia Armelle
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.59-68, tab., bibliogr. 32 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The incomplete combustion of organic matter results in the release of mixtures of greenhouse gases and other airborne pyrolysis products, including polycyclic aromatic hydrocarbons, which are capable to form dNA adduct after metabolic activation. DNA addducts are a biomarker that reveals xenobiotic exposure, possibly predictive of cancer risk. We have examined the association between environmental exposures and DNA adducts in selected dosimeter studies. In the Epic-Florence cohort, DNA adducts were significantly higher for traffic workers in respect to random sample. Urban residents tended also to show higher DNA adduct levels than those resident in suburban areas. In a meta-analysis of thirteen 32-postlabelling studies on occupational cohorts, the formation of DNA adducts was significantly associated with external levels of air pollutants, such as benzo(a)pyrene. However, a significant inter-individual variation in the levels of DNA adducts for apparently similar occupational exposure levels has been found. Thus, we have evaluated the role of genetic susceptibilities and different dietary intakes in influencing adduct formation. Our findings suggest the involvement of XPD, XRCC1 and XRCC3 genes in the repair of aromatic DNA adducts and the involvement of XRCC3 gene in teh repair of endogenous adducts. Our study supports also the protective effects of frequent consumption of fresh fruit and vegetables against aduct production.

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