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Zapytanie: PEDERSEN
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Tytuł oryginału: Prevalence and risk factors for airway diseases in farmers - summary of results of the European Farmers' Project.
Autorzy: Radon Katja, Monso Eduard, Weber Christoph, Danuser Brigitta, Iversen Martin, Opravil Ulrike, Donham Kelley, Hartung J”rg, Pedersen Soeren, Garz Susanne, Blainey David, Rabe Uta, Nowak Dennis
Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.207-213, il., tab., bibliogr. 24 poz.
Sygnatura GBL: 313,158

Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the European Farmers' Project was to determine prevalence and risk factors of respiratory diseases in farmers across Europe. A cross-sectional study in 7 centres was carried out. In the first stage of the study, nearly 8000 farmers in Denmark, Germany, Switzerland, the UK, and Spain answered a standardised questionnaire on farming characteristics and respiratory symptoms. The second stage of the study included exposure assessment and lung function measurements in 4 of the centres. Within the group of farmers, pig farmers were at high risk of asthma-like syndrome as compared to farmers keeping other kinds of animals. Among plant farmers, greenhouse workers were at higher risk for symptoms of asthma. The prevalence of symptoms of allergies were significantly lower among animal farmers as compared to the population of the European Community Respiratory Health Survey. In contrast, animal farmers had a signifcantly higher prevalence of symptoms of chronic bronchitis. The major risk factor for respiratory symptoms was shown to be ventilation of the animal houses and greenhouses. Intervention studies are now warranted to test the effectiveness of improved ventilation on respiratory health. The reasons for the low prevalence of allergic diseases among farmers are currently under study.


    Tytuł oryginału: Uric acid is a main electron donor to peroxidases in human blood plasma.
    Autorzy: Padiglia Alessandra, Medda Rosaria, Longu Silvia, Pedersen Jens Z., Floris Giovanni
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR454-BR459, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Background: Peroxidases are widely distributed and have been isolated from many higher-order plants, animal tissues, yeast and microorganisms. During measurements of peroxidase activities in samples of human plasma, we noticed the presence of a compound in the plasma which was interfering with the peroxidase assay. In this paper we describe the purification and characterization of this factor, which was identified as uric acid. Material/Methods: The procedure used to purify uric acid from plasma involved ultra-filtration of the plasma, heat denaturation, DEAE-cellulose chromatography, and high performance liquid chromatography. The lyophilized powder was tested for homogeneity using an HPLC apparatus and capillary electrophoresis. Genuine uric acid samples were used for comparison. Results: The compound obtained by the above-reproted purification procedure was identified as uric acid by spectrophotometric analysis through comparison with genuine uric acid samples. Spectrophotometric measurements indicated that uric acid was degraded by HRP in the presence of H2Os. Conclusion: The experimental procedures described above allowed us to isolate and identify uric acid as the component in human plasma that acts as a true substrate for peroxidases.

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