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Tytuł oryginału:
Interaction of monoamine transporter genes and personality dimensions.
Autorzy:
Rybakowski
Filip,
Samochowiec
Jerzy,
Zakrzewska
Marzena,
Czerski
Piotr,
Stępień
Genowefa,
Pełka-Wysiecka
Justyna,
Hauser
Joanna,
Horodnicki
Jan,
Rajewski
Andrzej,
Rybakowski
Janusz K.
Źródło:
Arch. Psychiatr. Psychother. 2002: 4 (2) s.17-24, tab., bibliogr. 26 poz.
Sygnatura GBL:
313,554
Hasła klasyfikacyjne GBL:
genetyka
psychiatria i psychologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
There is evidence for an association between allelic wariants of the monoamine transporter genes and the temperamental personality traits. Recent findings show that also an interaction of the different genes may contribute to the personality factors. Character dimensions of personality, which theoretically depend mainly on the ontogenetic development, were suggested to be under the genetic influence as well. We studied the association between personality dimensions measured with Temperament and Character Inventory (TCI) and polymorphism of the dopamine (DAT), norepinephrine (NET) and serotonin (5-HTT) transporter genes. The sample studied consisted of 128 healthy volunteers: 76 females and 52 males, mean age 23.8 ń 1.7 years, derived from two cities in the western part of Poland. We found statistically significant association between character dimension of Self-Directedness (SD) and NET polymorphism. There was a statistically significant effect of the interaction of NET and DAT polymorphisms on the dimension of Self-Transcedence (ST). The temperamental dimension of Reward Dependence (RD) was associated with interaction of 5-HTT and DAT polymorphisms. Character dimensions of personality, Self-Directedness and Self-Transcendence were associated with genetic differences. Interaction effect of the transporter polymorphisms was demonstrated in the Self-Transcendence and Reward Dependence dimensions. These findings warrant further study on the interplay of the different genes contributing to the complex traits.
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