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Zapytanie: PAUL-CLARK
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Tytuł oryginału: The annexin-1 knockout mouse: what it tells us about the inflammatory response.
Autorzy: Roviezzo F., Getting S. J., Paul-Clark M. J., Yona S., Gavins F. N. E., Perretti M., Hannon R., Croxtall J. D., Buckingham J. C., Flower R. J.
Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.541-553, il., tab., bibliogr. 85 poz.
Sygnatura GBL: 302,092

Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postilated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release. Immuno-neutralisation or antisense strtegies support this hypothesis as they can reverse the effect of glucocorticoids in several systems. We recently generated a line of mice lacking the Anx-1 gene noting that some tissues taken from such animals exhibited an increased expression of several proteins including COX-2 and cPLA2. In models of experimental inflammation, Anx-1 mice exhibit an exaggerated response and a partial or complete resistance to the anti-inflammatory effects leukocyte adhesion molecule expression, an increased spontaneous migratory behaviour of PMN in Anx-1 mice and a resistance in Anx-1 macrophages to glucocorticoid inhibition of superoxide generation. This paper reviews these and other data in the light of the development of the 'second messenger' hypothesis of glucocorticoid action.

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