Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy.
Autorzy: Jurgilewicz Dorota H., Rogowski Franciszek, Łebkowska Urszula, Citko Anna, Jaroszewicz Ewa, Parfieńczyk Adam
Źródło: Nucl. Med. Rev. 2002: 5 (1) s.39-42, il., bibliogr. 11 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • immunologia
  • radiologia
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: among cytokines-interleukins: -6 and -8 (IL-6, IL-8) and E-selectin (E-sel.), L-selectin (L-sel.) and intercellular cell adhesion molecue-1 (ICAM-1) are the most important links in the initiation of the inflammatory process. Taking into account that the inflammatory process is te basic stage of effective radioiodine therapy, we tried to compare the behaviour of the initial inflammatory factors in the early period of I-131 therapy (RAI) of hyperthyroidism. The aim of the study was to estimate the behaviour of IL-6, ICAM-1, E-selectin and L-selectin concentrations in the serum of patients with hyperthyroidims before and during I-131 therapy. Material and methods: The gorups of 26 patients with Graves' diseases (GD) and 18 patients with toxic nodula goiter (TNG), aged 34-77, were studied. Control group (C) consisted of 10 healthy volunteers. For estimation of thyroid function serum concentrations of TSH, free T4 and free T3 were measured by IRMA or RIA kits (Polatom, Poland). IL-6, ICAM-1, E-selectin and L-selectin serum concentrations were determined using ELISA method by Bender kits (USA). Blood samples for all estimations were taken 1-12 days before and in 6th week after I-131 administration. Treatment dose of radioiodine was calculated, basing on modified equation for absorbed dose. Results: Compared to control, no statistical differences in the level of E-selectin (C - 44.4 ń 11 ng/ml) and L-selectin (C - 842 ń 168.9 ng/ml) were observed before treatment in the patients with GD (E-sel. - 59.8 ń 19.6 ng/ml; L-sel-1288.2 ń 273.5 ng/ml) and with TNG (E-sel...

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