Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 2



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Tytuł oryginału: A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time.
Autorzy: Hliniak A., Gwiazdowska B., Szutkowski Z., Kraszewska E., Kukolowicz P., Jarząbski A., Sochacka B., Mazurkiewicz M., Paprota K., Oliskiewicz W., Zadrożna O., Milecki P., Kubiak M., Czopkiewicz L., Jagas M., Góźdź S., Wieczorek A., Woytowicz A., Cisowska B., Magdziarz H., Nowakowski S., Kośniewski W., Laskosz I., Serafin A., Gradoń E.
Źródło: Radiother. Oncol. 2002: 62 (1) s.1-10, il., tab., bibliogr. 13 poz.
Sygnatura GBL: 312,846

Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background and purpose: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. Materials and methods: Patietns with ó 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, NO, MO, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thrusday). A total of 395 patients were included from 05.1995 to 12.1998. Results. Early toxicity: At the end of radiotherapy patietns treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P = 0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P = 0.001) were similar in the two groups. Locoregional control: comparison between CF and AF showed no difference in terms of loco-regional control (P = 0.37). Conclusions: The improvement in AF in terms of loco-regional control is estimated to be 3-5 p.c. in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.


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    Tytuł oryginału: Odległe wyniki leczenia skojarzonego z udziałem przedoperacyjnej chemioterapii i resekcji u chorych na miejscowo-zaawansowanego niedrobnokomórkowego raka płuca.
    Tytuł angielski: Late results of the combined treatment with the use of preoperative chemiotherapy and surgery of locally advanced non-small cell lung cancer.
    Autorzy: Furmanik Franciszek, Paprota Krzysztof, Kaczmarek-Borowska Bożena, Budny Bożena, Sawicki Marek, Korobowicz Elżbieta, Zdunek Małgorzata, Jabłonka Andrzej, Jabłonka Stanisław
    Źródło: Pneumonol. Alergol. Pol. 2002: 70 (1/2) s.34-43, il., tab., bibliogr. 27 poz., sum.
    Sygnatura GBL: 301,096

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study is the assessment of efficacy of combined treatment (preoperative chemotherapy and surgery of locally advanced non-small cell lung cancer. Material included sixty-two NSCLC patients treated in the Department of Thoracic Surgery of Medical School of Lublin between February 1993 and October 1997. Treatment was started with 2 or 3 courses of chemotherapy. In 51 cases chemotherapy was based on Cisplatin. Response (CR + PR) to chemotherapy was observed in 30 cases (48,8 p.c.). 21 - 25 days after last course of chemotherapy resections were carried out. In 1 case it was lobectomy, in 25 cases -pneumonectomy and in 36 - extended pneumonectomy. In 56 cases resection was radical, in 6 cases non-radical. No perioperative deaths or bronchial fistulas were observed. Median survival was 21,4 months and 5-years survival - 35,25 p.c. The results confirm the usefulness of preoperative chemotherapy in locally advanced NSCLC.

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