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Tytuł oryginału: Estimation of usefulness of monitoring tissue polypeptide antigen - TPA-M concentrations in the effectiveness of surgical treatment of urinary bladder cancer.
Autorzy: Kochańska-Dziurowicz Aleksandra A., Mielniczuk Michał J., Bijak Aleksandra, Palugniok Ryszard
Źródło: Nucl. Med. Rev. 2002: 5 (2) s.109-111, il., tab., bibliogr. 13 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • chirurgia
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: Of all cancer tumours, urinary bladder cancer is the fourth must common in men and the seventh in women. The aim ofthis work was to answer the queation whether tissue polypeptide antogen (TPA-M) determination in patients afetr electroresection of urinary bladder cancer can be used to estabilish the probability of tumour recurrence. Material and methods: The research included 98 patients, all of wwhom had undertaken electroresection of urinary bladder tumour (TURT), wwhich enabled its removal, and then estimation of malignancy and progression stage according to the international TNM scale. The mean age was 62.7 years. All patients had blood samples taken to determine TPA-M and then underwent routine cystoscopy examination. Results: The patients with tumour recurrence (60, mean age 64 ń 10) had TPA 30.2 ń 4.3 U/l, the patients without recurence (38, mean age 61.3 ń 11) had TPA-M 26.2 ń 3.118 U/l (p 0.1). Taking the TPA-M threshold point 85 U/l as normal, true-positive results were 16.3 p.c., true-negative were 31.6 p.c., false-positive results were 7.1 p.c. false-negative were 44.9 p.c. The ROC curves with the calculated area under them are the measurement of the diagnostic estimation of TPA-M concentrations in specificity and sensitivity categories. Conclusions: For the examined group the calculated P was 0.45. If P value is under 0.5 it is considered that the test should not be used in diagnosing reccurrence of urinary bladder cancer.

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