Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Interakcje układu glutaminianergicznego z cynkiem.
Tytuł angielski: Interactions of glutamatergic system with zinc.
Autorzy: Pilc Andrzej, Pałucha Agnieszka
Źródło: Farm. Pol. 2002: 58 (10) s.466-470, bibliogr. 18 poz., sum. - Sympozjum pt. Cynk w fizjologii oraz w patofizjologii i terapii depresji Kraków 06.12. 2000
Sygnatura GBL: 310,851

Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Zn is the second most prevalent trace element in the body and is present in particularly large concentrations in the mammalian brain. Although Zn is a cofactor for many enzymes in all tissues, a unique feature of brain Zn is its vesicular localization in presynaptic terminals, where its release is dependent on neural activity. Synaptic Zn, influencing excitatory glutamate, probably plays a modulatory role in synaptic transmission. This paper reviews glutamatergic system, including ionotropic and metabotropic glutamate receptors, and its role of zinc in the modulation of excitatory transmission.

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    Tytuł oryginału: Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus.
    Autorzy: Śmiałowska M., Szewczyk B., Brański P., Wierońska J. M., Pałucha A., Bajkowska M., Pilc A.
    Źródło: Neuropharmacology 2002: 42 (8) s.1016-1023, il., bibliogr. s. 1022-1023
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Previous studied showed that chronic electroconvulsive shock (ECS) or impiramine treatment induced a subsensitivity of group I metabotropic glutamate receptors (mGluR) in hippocampus. In the present study effects of antidepressant treatment on the expression og mGluR1a and mGluR5a, belonging to the group I mGluR, were investigated in rat brain hippocampus using immunohistochemical and Western blot methods, respectively. Male Wistar were treated singly or chronically for 21 days with imipramine, 10 mg/kg, twice daily; with ECS (90 mA, 50 Hz, 0.5 s) every second day; or with haloperidol, 1.2 mg/kg, once daily. Appropriate controls were injected with saline. Rats were sacrificed 24 h after last treatment and their hippocampi were taken out for analysis. It was found that the mGluR1a-immunoreactivity expression increased significantly in Ammon's horn (CA) regions after chronic ECS. The most pronounced effect was observed in the CA3. No significant effects were found after single treatment or after haloperidol. The expression of mGluR5a increased significantly after chronic impiramine in the CA1 and after chronic ECS in the CA3 region. The results obtained indicate an influence of antidepressant treatment on group I mGluR. This increase in the receptor protein level may be a compensatory mechanism developing after chronic treatment.

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    Tytuł oryginału: Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
    Autorzy: Pilc A., Kłodzińska A., Brański P., Nowak G., Pałucha A., Szewczyk B., Tatarczyńska E., Chojnacka-Wójcik E., Wierońska J. M.
    Źródło: Neuropharmacology 2002: 43 (2) s.181-187, il., tab., bibliogr. s. 186-187
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Several lines of evidence suggest a crucial involvement of glutamate in the mechanism of action of anxiolytic and antidepressant drugs. The involvement of group I mGLu receptors in anxiety and depression has also been proposed. In view of the recent discovery of anxiolytic- or antidepressant-like effects of acute injections of 2-methyl-6-(phenylethyl)-pyridine (MPEP), a selective and brain penetrable mGlu5 receptor antagonist, we designed the present study to examine anxiolytic- and/or antidepressant-like effects of multiple administration of this drug. The anxiolytic-like effects of MPEP were evaluated in rats using the conflict drinking test. The antidepressant-like effect was estimated using the rat olfactory bulbectomy model of depression. Seven subsequent injections of MPEP (1 mg/kg) significantly (by 320 p.c.) increased the number of shock accepted during the experimental session in the Vogel test. MPEP given once daily at a dose of 10 mg/kg, restored the learning deficit of bulbectomized rats after 14 days of treatment, remaining without any effect in the sham-operated animals. N-methyl-D-aspartic acid (NMDA)-induced convulsions in mice were not affected by a single injection of MPEP (30 mg/kg) indicating that at this dose MPEP did not block NMDA receptors. The results indicate that the prolonged blockade of mGlu5 receptors exert anxiolytic- and antidepressant-like effects in rats. No tolerance to anxiolytic-like action occurs. The previously mentioned results further indicate that antagonists of group I mGlu receptors may play a role in the therapy of both anxiety and depression.

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    Tytuł oryginału: On the role of metabotropic glutamate receptors in the mechanisms of action of antidepressants.
    Autorzy: Pałucha Agnieszka, Pilc Andrzej
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.581-586, bibliogr. 50 poz., sum.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Most conventional antidepressant drugs influence serotoninergic adrenergic, and/or dopaminergic systems, increasing serotonin, norepinephrine and dopamine synaptic availability. More recently has focused on glutaminergic system. Both preclinical and clinical studies, showing antidepressant-like actions of compounds which reduce transmission at N-methyl-D-aspartate (NMDA) receptors, indicate possible involvement of glutamatergic system in the etiology of depression. Since glutamatergic transmission is controlled not only by inotropic but also by metabotropic glutamate receptors (mGluR), their involvement in the etiology and the therapy of depression was also postulated. Recent studies, showing that antidepressant treatment may influence mGlu receptors, together with the findings that group I mGluR antagonists, may possess antidepressant-like action, support this hypothesis.

    5/6

    Tytuł oryginału: Interaction of zinc with antidepressants in the forced swimming test in mice.
    Autorzy: Szewczyk Bernadeta, Brański Piotr, Wierońska Joanna M., Pałucha Agnieszka, Pilc Andrzej, Nowak Gabriel
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.681-685, tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Recent preclinical data have suggested that glutamate NMDA receptor may be involved in the mechanism of action of antidepressant treatments. Functional antagonists of the NMDA receptor complex exhibit an antidepressan-like effect in animal tests that predict antidepressant activity and in animal models of depression. Zinc, a very potent inhibitor of the NMDA receptor, is active in the forced swimming test in rats and mice. The present study investigated the interaction of zinc with antidepressants in the forced swimming test in mice. Mice were injected with imipramine or citalopram alone and in combination with zinc. Low, ineffective per se doses of imipramine and citalopram administered together with low, ineffective doses of zinc were active in this test. The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demostrate particular role of zinc in this activity.

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    Tytuł oryginału: Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.
    Autorzy: Tatarczyńska Ewa, Pałucha Agnieszka, Szewczyk Bernadeta, Chojnacka-Wójcik Ewa, Wierońska Joanna, Pilc Andrzej
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.707-710, tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.

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