Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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PŁOTKOWIAK
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Tytuł oryginału:
Kinetics of talampicillin decomposition in solutions.
Autorzy:
Pawełczyk
Ewaryst,
Płotkowiak
Zyta,
Helska
Maria
Źródło:
Acta Pol. Pharm. 2002: 59 (1) s.25-29, tab., bibliogr. 9 poz.
Sygnatura GBL:
301,378
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Streszczenie angielskie:
Talampicillin stability in aqueous solutions was studied in a broad range of pH values using as medium solutions of hydrochloric acid (pH 0.4 - 1.8), phosphate buffers (pH 2.05 - 3.13 and 6.03 - 8.04), acetate buffer (pH 3.87-5.28) and borate buffer (pH 8.90 - 9.10) as well as sodium hydroxide solution (pH 11.48). For the determination of talampicilin concentration changes in kinetic studies, two methods were used: iodometric and spectrophotometric in UV(lambdamax = 254.5 nm). The catalytic velocity constans (kh+, kx, ko) were established, the log k-pH profile (35řC) was found, thermodynamic parameters were calculated of the hydrolisis reaction of the á-lactam bond (kH+: EA=67.9 kJ mol**-1, Delta S"= -92.4 JK**-1 mol-1, Delta G"=92.6 kJ mol**-1; kx:EA = 31.8 kJ mol**-1, Delta S" = 347.1 JK**-1 mol**-1, Delta G" =131.1 kJ mol**-1...
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Tytuł oryginału:
Sterility and antibacterial activity of some antibiotics sterilized by irradiation.
Autorzy:
Muszyński
Zygmunt,
Długaszewska
Jolanta,
Marciniec
Barbara,
Płotkowiak
Zyta,
Popielarz-Brzezińska
Maria,
Ogrodowczyk
Magdalena
Źródło:
Acta Pol. Pharm. 2002: 59 (6) s.433-435, tab., bibliogr. 13 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
Sygnatura GBL:
301,378
Hasła klasyfikacyjne GBL:
mikrobiologia
farmacja
Typ dokumentu:
praca związana ze zjazdem
praca doświadczalna
tytuł obcojęzyczny
Streszczenie angielskie:
Sterility and antibacterial activity of several antibiotics (including some penicillins and their salts, gramicidin and neomycin) subjected to sterilization by irradiation has been studied. The compounds in solid phase have been exposed to gamma irradiation in air atmosphere at room temerature, with a dose of 25 kGy, and afterwards they have been subjected to tests recommended by FP V (volume I, 1990) checking their sterility and activity. The results have shown that the majority of initial compounds have been to a slight degree contaminated by bacteria from the genera Bacillus and Micrococcus, the number of bacteria did not exceed 10ý CFU, and fungi up to 10 CFU in 1 g of the compouned. All compounds subjected to sterilization with a dose of 25 kGy were sterile and preserved the activity required by FP V. The decrease in activity observed for some compounds was always within the limits of FP specification. The results have proved that the penicillins analysed, gramicidin and neomycin can be sterilized by irradiation with a dose of 25 kGy, without any detrimental effect on their properties and antibacterial activity.
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