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Tytuł oryginału: Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome.
Autorzy: Haban Peter, Simoncic Robert, Zidekova Eva, Ozdin Lubomir
Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR175-CR179, il., tab., bibliogr. 18 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Insulin resistance with increased insulin and C-peptide levels is the basis of the metabolic X-syndrome, so it is reasonable to expect them to be a good predictor of associated cardiovascular risk factors. Material/Methods: A total of 29 paitents (21 postmenopausal women and 8 men) with type 2 diabetes mellitus (mean duration 14.6 years, 95 p.c. CI 11.9 to 17.3 years), all older than 50, were studied for possible links between fasting serum C-peptide levels and other vascular risk factors. The mean value of the C-peptide in the group was 0.627 nmol/l (95 p.c. CI: 0.464 to 0.789 nmol/l). Results: We found statistically signifcant correlations between C-peptide and traicylglycerosl (TG; r - 0.474; p = 0.009), HDL-cholesterol (inverse; r = -0.567; p = 0.001) and various lipoprotein rations: atherogenic index (= total/DHL cholesterol: r = 0.599; p = 0.0006) or TG/HDL (r = 0.587; p = 0.0008). C-peptide also correlated with the body mass index (BMI: r = 0.519; p = 0.004) and leptin (r = 0.492; p = 0.007). After the coefficient CpG (C-epeptide x fasting glycemia) was introduced, the correlations with lipoproteins became even stronger. Conclusion: We suggest that elevated (fasting) serum C-peptide levels constitute a clinically important marker of the cardiovascular risks associated with the metabolic X-syndrome. It can be used as an effective tool for the early detection of diabetic patients at particular risk for atherosclerotic cardiovascular diseases and needing early preventive measures or aggressive treatment.

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