Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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Tytuł oryginału:
The association study of a functional polymorphism of the monoamine oxidase A gene promoter in patients with affective disorders.
Autorzy:
Hauser
Joanna,
Leszczyńska
Anna,
Samochowiec
Jerzy,
Ostapowicz
Agata,
Czerski
Piotr,
Jaracz
Jan,
Suwalska
Aleksandra,
Horodnicki
Jan,
Rybakowski
Janusz
Źródło:
Arch. Psychiatr. Psychother. 2002: 4 (2) s.9-15, tab., bibliogr. 19 poz.
Sygnatura GBL:
313,554
Hasła klasyfikacyjne GBL:
psychiatria i psychologia
genetyka
Typ dokumentu:
tytuł obcojęzyczny
praca kliniczna
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
Streszczenie angielskie:
Recently a functional 30 bp variable number of tandem repeat polymorphism (VNTR) in the promoter region of the MAO-A gene was identified, which was shown to be associated with MAO-A transcriptional activity. Variation in the number of repeats (3 - 5) displayed a 2.7 - 4.8 fold increased transcription activity for allele containing four or five repetitive elements than allele containing three repectitive elements. In the present study we investigated this polymorphism in 78 male and 122 female patients with bipolar and unipolar affective disorders, and in 221 control subjects. There were significant differences in the alleles and genotypes frequencies between the group of females with bipolar affective illess compared to the controls and compared to the unipolar female subjects. No differences were found in genotype distribution between unipolar female patients and control group and between bipolar and unipolar male subjects comparing to the controls. We suggest that the association may exist between uVNTR polymorphism in MAO A gene and bipolar affective disorders in women.
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