Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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OPATRNY
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Tytuł oryginału:
Fibrinolysis in chronic renal failure, dialysis and renal transplantation.
Autorzy:
Opatrny
K.,
Zemanova
P.,
Opatrna
S.,
Vit
L.
Źródło:
Ann. Transplant. 2002: 7 (1) s.34-43, il., bibliogr. 70 poz.
Sygnatura GBL:
313,259
Hasła klasyfikacyjne GBL:
transplantologia
nefrologia
toksykologia
Typ dokumentu:
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
zwierzęta
Streszczenie angielskie:
The best known function of the fibrinolytic system is its ability to dissolve blood clots. The key enzyme of fibrinolysis, plasmin, is formed by conversion from plasminogen through the action of activators, the most important of which is tissue type plasminogen activator (tPA). Low levels of tPA or excessive levels of plasminogen activator inhibitor-I (PAI-I) cause hypofibrinolysis, causally related to the development of atherosclerosis and associated thrombotic complications, as well as with the development of venous and arterial thrombosis. A chronic decrease in renal function leads to hypofibrinolysis due primary to low levels of tPA. Hypofibrinolysis is present both in patients treated by long-term hemodialysis and by peritoneal dialysis. The hemodialysis procedure acutely raises the plasma levels of tPA, primarily as a result of the bioincompatibility of materials in the extracorporeal circuit. In peritoneal dialysis, dialysis solution dwell time is associated with an increase in PAI-I levels in the abdominal cavity. Fibrinolysis defects occur also in renal transplant recipients. In transplant patients, the main abnormality is also hypofibrinolysis which, however, unlike the situation with the other methods of renal replacement therapy, is secondary to a rise in PAI-I. A role in the increase of the plasma levels of PAI-I in transplant patients is played by steroid-and cyclosporine-based immunosuppression, most likely by metabolic disorders such as insulin resistance or dyslipoproteinemia, and by genetic factors. Animal experiments ...
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