Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: OMULECKA
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Tytuł oryginału: Ocena komórek nabłonka soczewki w mikroskopie świetlnym i elektronowym oraz metodami immunohistochemicznymi w zaćmach różnego typu.
Tytuł angielski: A study of human lens epithelial cells by light and electron microscopy and by immunohistochemistry in different types of cataracts.
Autorzy: Synder Aleksandra, Omulecka Aleksandra, Ratyńska Marzena, Omulecki Wojciech
Źródło: Klin. Oczna 2002: 104 (5/6) s.369-373, il., tab., bibliogr. 10 poz., sum.
Sygnatura GBL: 301,280

Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Purpose: To evaluate the characteirstis of cataract changes in lens epithelial cells (LECs), in different types of human cataract. Material and metods: Anterior capsules for the study were obtained from patients with different types of cataracts during extracapsular cataract extraction, or phacoemulsification using continuous curvilinear capsulorhexis. LECs attached to the anterior capsules were analyzed for morphological changes by light and electron microscopy, and for cellular characteristics by immunohistochemsitry. The reactivity to cytokeratins 5,6,8,17 ane 19 (arker of epithelial cells) and to vimentin (arker for mesenchymal cells) was determined. Results: The consecutive degenerative changes were observed in most of the cells: multilayered cells, nuclei of abnormal diameters adn shapes, vacuolation of nuclei and cytoplasm. LECs were immunohistochemically positive for cytokeratin and vimentin, or only for vimentin in all types of cataract. Some of LECs showed morphological and immunohistochemical characteristics of mesenchymal cells. Conclusions: Lens epithelial cells show simmilar degenerative changes in different types of cataract and may have the ability to transdifferentiate into mesenchymal cells.

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