Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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NOSIKOV
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Tytuł oryginału:
Further studies of genetic susceptibility to Graves' disease in a Russian population.
Autorzy:
Chistiakov
Dimitry A.,
Savost'anov
Kirill V.,
Turakulov
Rustam I.,
Petunina
Natal'ya,
Balabolkin
Mikhail I.,
Nosikov
Valery V.
Źródło:
Med. Sci. Monitor 2002: 8 (3) s.CR180-CR184, il., tab., bibliogr. 27 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
genetyka
endokrynologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Background: Graves' disease (GD) is a polygenic autoimmune thyroid syndrome. Some of the genes implicated in its pathogenesis may encode thyroid-stimulating hormone receptor (TSHR) and estrogen receptors 1 (ESR1) and 2 (ESR2). We examined dinucleotide repeat polymorphisms in the ESR1 and ESR2 genes and D727E amino acid substitution in the TSHR gene for possible association with GD in a Russian population. Material/Methods: The polymorphic regions of the target genes were amplified by polymerase chain reaction (PCR) on the basis of genomic DNA isolated from blood of 78 unrelated Russian patients with GD and 93 control subjects. TO detect the D727E TSHR polymorphism, the PCR product was additionally digested with Eco721 restriction endonuclease. The genotype and allele frequencies in the groups studied were compared by chi-squared test. The odds ratios and 95 p.c. confidence intervals (CI) were calculated to assess the strength of the relationship between the polymorphisms tested and GD. Results: For polymorphic dinucleotide microsatellites at ESR1 and ESR2, no significant difference was observed in allele frequencies between affected and nonaffected patients. For the D727E TSHR polymorphism, the E allele and the DE genotype were significantly more frequent (p 0.0001) in patients with GD than in control subjects. Conclusions: The D727E variant of the TSHR gene is associated with Graves' disease in a Russian population. The E727 allele and the heterozygous D727E genotype are realated to higher risk of the disease. No association with GD was found for polymorphic microsatellites of the ESR1 and ESR2 gene.
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