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Tytuł oryginału: Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: a main role for MHC-unrestricted T cells.
Autorzy: Agrati Chiara, Nisii Carla, Oliva Alessandra, D'Offizi Gianpiero, Montesano Carla, Pucillo Leopoldo Paolo, Poccia Fabrizio
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.307-316, il., bibliogr. 103 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Hepatitis C virus (HCV) infection induces an acute and chronic liver inflammation through an immune-mediated athway that may lead to cirrhosis and liver failure. Indeed, HCV-related hepatitis is characterized by a dramatic lymphocyte infiltrate into the liver which is mainly composed by HCV non-specific cells. Several data indicated that interferon (IFN)-ç secretion by intrahepatic lymphocytes 9IHL) may drive non-specific cell homing to the liver, inducing interferon inducible protein-10 9p-10) production. An interesting hallmark of these IHL is the recruitment of lymphocytes associated with mechanisms of innate immunity, such as natural killer (NK), natural killer T (NKT) and çë T lymphocytes. CD81 triggering on NK cell surface by the HCV envelope glycoprotein E2 was recently shown to inhibit NK cell function in the liver of HCV-infected persons, resulting in a possible mechanism contributing to the lack of virus clearance and to the establishment of chronic infection. In contrast, intrahepatic NKT cells restricted to CD1d molecules expressed on the hepatocyte surface may contribute to a large extent to liver damage. Finally, an increased frequency of T cells expressing the çë T cell receptor (TCR) was observed in HCV-infected liver and recent observations indicate that intrahepatic çë T cell activation could be directly induced by the HCV/E2 particle through Cd81 triggering. These cells are not HCV specific, are able to kill target cells including primary hepatocytes and their ability to produce T helper (Th)1 cytokines is associated with a higher degree of liver disease...

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