Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: NIEMIROWSKA-MIKULSKA
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Biodostępność izoniazydu u zdrowych ochotników - szybkich i wolnych acetylatorów INH.
Tytuł angielski: Bioavailability of isoniazid in healthy volunteers fast and slow INH acetylstors.
Autorzy: Augustynowicz-Kopeć Ewa, Zwolska Zofia, Niemirowska-Mikulska Hanna
Źródło: Pneumonol. Alergol. Pol. 2002: 70 (3/4) s.167-179, il., tab., ibliogr. 32 poz., sum.
Sygnatura GBL: 301,096

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The major pathway for INH metabolism is acetylation of acetyloisoniazid by a noninducible hepatic enzyme N-acetyltransferase. Examples of drugs acetylated by thisenzymatic system are: isoniazid, sulphadimidine, hydralazine, dapson and sulphapiridine. The rate of acetylation is constant in any individual but varies in different patients. People are characterized as rapid or slov acetylators with slow acetylation inherited as an autosomal recessive type. Heterozygotes have intermediate acetylation rate. Methods for determining acetylator phenotype have been proposed by many authors, but the many of them need instrumentation such as photometers, centrifuges, chromatographs ect. For estimating of INH acetylator phenotype we have developed a sensitive and rapid biological method with Mycobacterium aurum REB as a standard strain. The linearity, precision and accuracy of the method have been evaluated. The minimum detectable concentration of INH was determined to be 0,5 mcg/ml. The test should be completed within 5 days. The described method for determination of INH in human plasma is sensitive and reproducible and allowed to provide pharmacokinetic studies in fast (8 healthy volunteers) and slow (12 healthy volunteers) acetylators. The results have shown that all compared parameters are significantly different in both groups of acetylators.


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    Tytuł oryginału: The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule.
    Autorzy: Zwolska Zofia, Augustynowicz-Kopeć Ewa, Niemirowska-Mikulska Hanna
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.448-452, il., tab., bibliogr. 10 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: A study was performed at the National Tuberculosis and Lung Diseases Research Institute (NTLDRI) in Warsaw according to the protocol by the Ethics Committee of the Institute. The main target of the mentioned study was a comparison of the biavailability of rifampicin, isoniazid and pyrazinamid fixed together in one capsule with the bioavailability of the same doses of these drugs, which were given sepatately. The absorption of rifampicin, isoniazid and pyrazinamid were tested after oral administration of each drug in free simultaneous combinations and in a fixed-dose combination of three drugs - Triazid. The study was carried out as an open randomised crossover experiment comprising 16 volunteers. The results have shown that the pattern of absorption, plasma concentrations and pharmacokinetic parameters were found to be very simular after administration of the drugs in free and fixed combinations. The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis.

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