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Tytuł oryginału: General model to describe the structure and dynamic balance between different human serum lipoproteins and its practical application.
Autorzy: Tuzikov Fedor V., Tuzikova Nataliya A., Galimov Ravil V., Panin Lev E., Nevinsky Georgy A.
Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT79-MT88, il., tab., bibliogr. 36 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Many dangerous diseases are associated with changes in the concentration of blood lipoiproteins (LPs). Thus a fast and accurate method is needed to determine the composition of lipoprotein fractions in human serum. A comparison of 30 parameters characterizing different LPs in serum from 120 healthy donors and 102 multiple sclerosis patients was carried out using a unique algorithm developed to determine the concentrations of all the main lipids and apolipoproteins in each LP fraction and subfarction. Specially developed computer programs and the small-angle X-ray scattering (SAXS) method were used to analyze the literature and experimental data. A general mathematical model has been developed to descrie the structure and equilibrium between various LPs, from high density to chylomicrons. All human serum LPs can be regarded as spherical particles, composed of a lipid hydrophobic spherical core consisting of triglycerides and cholesterol esters, and a hydrophilic shell of free cholesterol, phospholipids and apolipoproteins. We show for the first time that the distribution of components among various LP particles can be described by a system of five basic equations and two additional balance equations. The observed difference between control subjects and MS patients was found to be statistically significant in 23 parameters. In contrast to traditional methods the new method for analyzing human blood LPs is very simple and relatively quick. LP - lipoproteins; HDL - high density lipoprteins; LDL - low density lipoproteins; VLDL - very low density lipoproteins; CM - chylomicrons; TG - triglycerides; FC - free cholesterol; CE - cholesterol ester; PL - phospholipids; P - apolipoproteins; LPL - lipoproteinlipase; H-TGL - hepatic triglyceridlipase; DLP - dyslipoproteinemia; SAXS - small-angle X-ray scattering.

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