Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: NASIŁOWSKI
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Tytuł oryginału: Krwisty, eozynofilowy wysięk w opłucnej w przypadku przedawkowania warfaryny.
Tytuł angielski: Hemothorax with high number of eosinophils following warfarine overdose.
Autorzy: Nasiłowski Jacek, Krenke Rafał
Źródło: Pneumonol. Alergol. Pol. 2002: 70 (9/10) s.496-503, il., tab., bibliogr. 18 poz., sum.
Sygnatura GBL: 301,096

Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • pulmonologia

    Streszczenie angielskie: Some drugs are known to induce pleural effusion. Drug-induced pleural effusion is often associated with pleural eosinophilia. Aantcoagulant therapy may induce pleural effusion by at least two different mechanisms: bleeding complication (haemothorax) and allergic or toxic reaction. Authors describe 76-yr-old male with warfarin-induced pleural effusion. Since INR was 15.5, and the value of pleural effusion Hct exceeded significantly 50 p.c. of Hct value in blood, spontaneous haemothorax due to warfarine overdose was diagnoed. Pleural fluid analysis revealed relatively high percentage of eosinophils (13 p.c.), but it was probably secondary to the presence of numerous red blood cells in the effusion. The authors discuss differernt mechanisms of drug-induced pleural effusion, with special attention to eosinophilic pleural effusion and review the literature on the spontaneous haemothorax as a complication of anticoagulant therapy.

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