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Tytuł oryginału: The future of knee ligament surgery.
Autorzy: Fu Freddie H., Musahl Volker
Źródło: Acta Clin. 2002: 2 (r1) s.101-107, bibliogr. 50 poz.
Sygnatura GBL: 313,595

Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Approximately 100,000 anterior cruciate ligament (ACL) reconstructions are being performed every year in the United States alone. Long-term clinical outcome can still not exceed 85 - 90 p.c. as a result of biological, biomechanical, and technical reasons. Biological incorporation of grafts in bone tunnels (bone-to-bone and bone-to-tendon healing) is still not completely understood and is currently subject of basic since research. Knowledge on in situ forces and in vivo strains in the ACL are the basis of rehabilitation regimens. Ultimately, healing and remodeling of the ACL graft needs to be improved. Gene therapy can be applied to the field of Orthopaedic surgery by transfer of defined genes encoding for growth factors into tareget tissues (e.g. ligamnet, cartilage or bone). Local cells at injury sites can then highly and persistently produce therapeutic proteins. Gene transfer techniqes in animal models have shown promising first results when enhancing graft incorporation. In addition, Computer Assisted Orthopaedic Surgery (CAOS) is now considered to add further precision and accuracy to knee ligament surgery. Passive and active systems are thereby distinguished. In the future, a simple muscle biopsy may be enough to provide the cell that can restore any kind of defect in the knee by growing the local cell line. With improved medical imaging techniques and surgical robotics, clinical outcome may be improved.

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