Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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MURAKAMI
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2
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Tytuł oryginału:
Cytotoxic effect of nitric oxide on human hematological malignant cells.
Autorzy:
Tsumori
Michihiro,
Tanaka
Junko,
Koshimura
Kunio,
Kawaguchi
Mikiko,
Murakami
Yoshio,
Kato
Yuzuru
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.139-144, il., tab., bibliogr. 10 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
farmacja
hematologia
onkologia
Typ dokumentu:
praca kliniczna
praca związana ze zjazdem
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
in vitro
Streszczenie angielskie:
We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.
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Tytuł oryginału:
Monitoring of urine nitric oxide (NO) related substrates and immunological competence in hematological malignancy.
Autorzy:
Tanaka
Junko,
Koshimura
Kunio,
Tsumori
Michihiro,
Murakami
Yoshio,
Kato
Yuzuru
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.227-232, il., tab., bibliogr. 10 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
immunologia
hematologia
onkologia
Typ dokumentu:
praca związana ze zjazdem
praca kazuistyczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myeolocytic leukemia. However, no significant correlation was observed between uring neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+16+ subset or serum IFN-ç levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and uring neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.
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