Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: MORI
Liczba odnalezionych rekordów: 6



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Tytuł oryginału: Hydrolysis of cortex peptidoglycan during bacterial spore germination.
Autorzy: Makino Shio, Moriyama Ryuichi
Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA119-RA127, il., tab., bibliogr. 58 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Despite the most extreme dormancy and resistance properties among living systems, bacterial endospores retain an alert sensory mechanism to respond to the germinants and initiate germination. Although the molecular mechanism of the germiantion process is not completely described, current progress in the studies on the enzymes involved in the process gave us a some what clearer picture of the process of spore peptidoglycan (cortex) hydrolysis, a major biochemical event in germination. Germiantion-specific cortex-lytic enzymes require muramic acid ë-lactam in their substrates. At least two types of enzymes are involved in the germination process: a spore cortex-lyticenzyme (SCLE) and a cortical fragment-lytic enzyme (CFLE). Except for their peptidoglycan-binding regions, the primary structures of SCLE and CFLE vary according species. Both enzymes differ in their hydrolytic bond-specificities and recognition of the substrates morphology. SCLE appears to initiat germination by uncrosslinking the intract cortex, and the CFLE further degrades the polysaccharide moiety of the SCLE-modified cortex. In vivo CFLE activity is likely regulated by its requirement for partially uncrosslinked cortex, while SCLE requires activation process. Clostridium perfringens SCLE is activated by a germination-specific serine protease during germination, but the activation mechanism of SCLE in Bacillus species is unknown. Cortex-lytic enzymes are expressed at the early stage of sporulation but the compartment of expression depends on proteins. However, all enzymes are located outside the cortex layer in dormant spores, suggesting that the hydrolysis process initiates at the exterior side of the cortex. The assembly of the germination apparatus is also discussed.

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    Tytuł oryginału: The KVLQT1 gene is not a common target for mutations in patients with various heart pathologies.
    Autorzy: Moric Ewa, Herbert Ernest, Mazurek Urszula, Samelska Justyna, Cholewa Krzysztof, Trusz-Gluza Maria, Wilczok Tadeusz
    Źródło: J. Appl. Genet. 2002: 43 (2) s.245-254, il., bibliogr. s. 253-254
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The long QT syndrome (LQTS) is a disorder of ventricular repolarization that exposes affected individuals to cardiac arrythmias and sudden death. The first gene for LQTS has been mapped to chromosome 11 p. 15.5 by genome-wide linkage analysis. This gene, originally named KVLQT1 (and later KCNQ1), is a novel potassium channel gene. Mutations in the human KVLQT1 gene, encoding the ŕ-subunit of the KVLQT1 channel, cause the long QT syndrome. In this work, we analysed the sequence of six KVLQT1 exons in patients with various heart pathologies. We describe 6 different mSSCP patterns with no disease-related SSCP conformes in any sample. Different sequencing of exons 2 to 7 confirmed the absence of mutations. This suggests that the analysed region of the KVLQT1 gene is not commonly involved in pathogenesis of the long QT syndrome.

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    Tytuł oryginału: The polymorphism of the HERG gene responsible for the autosomal dominant long-QT syndrome.
    Autorzy: Herbert Ernest, Trusz-Gluza Maria, Moric Ewa, Śmiłowska-Dzielicka Ewa, Mazurek Urszula, Wilczok Tadeusz
    Źródło: Folia Cardiol. 2002: 9 (3) s.193-202, il., tab., bibliogr. 64 poz.
    Sygnatura GBL: 313,196

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

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    Tytuł oryginału: Impedance pharyngography for diagnosis of swallowing disorders.
    Autorzy: Yamamoto Yoshitake, Nakamura Takao, Kusuhara Toshimasa, Mori Keiko
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.97-103, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Swallowing disorders are a serious problem occurring in association with cerebrovascular disorder, nerve or muscle disease, laryngeal or esophageal disease, or advanced age. Unfortunately, it is difficult to evaluate swallowing disorders quantitatively. For this reason, we previously proposed a new method, impedance pharyngography (IPG), for evaluating swallowing disorders noninvasively by measuring neck electrical impedance during swallowing. In this study, the efficacy of this method was tested in a cohort of patients with IPG and healthy controls. The change of neck electrical impedance in the pharyngeal phase is mainly caused by the changes in the equivalent cross-sectional area of the near epiglottis. In addition, the increase in equivalent cross-sectional area due to raising of the larynx caused a decrease in neck electrical impedance in the pharyngeal phase. In the case of healthy subjects, IPG results were highly reproducible, and the patterns were simple and similar. In subjects with advanced age, IPG are delayed-action, slowly changing and less reproducible, and showed various patterns among the subjects. In subjects with swallowing disorders IPG results were less reproducible and showed irregular variable patterns. We therefore conclude that the IPG pattern can be used effectively as a simple index of swallowing activity.

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    Tytuł oryginału: KCNQ1 gene mutations and the respective genotyp-phenotype correlations in the long QT syndrome.
    Autorzy: Herbert Ernest, Trusz-Gluza Maria, Moric Ewa, Śmiłowska-Dzielicka Ewa, Mazurek Urszula, Wilczok Tadeusz
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA240-RA248, il., tab., bibliogr. 62 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: KCNQ1 (formerly called KVLQT1) is a Shaker-like voltage-gated potassium channel gene responsible for teh LQT1 sub-type of LQTS. In general, heterozygous mutations in KCNQ1 cause Romano-Ward syndrome (LQT1 only), while homozygous mutations cause JLNS (LQT1 and deafness). To date, more than 100 families with mutations in this gene have been reported, most with their own novel 'private' mutations. The majority of these mutations are missense. However, other types of mutations, such as deletions, frame-shifts and splice-donor errors have also been reported. There is one frequently reported mutated region (the 'hotspot'). KCNQ1 is now believed to be the most commonly mutated gene in LQTS. The combination of normal and mutan;t KCNQ1 ŕ-subunits has been found to form abnormal I KS channels, hence mutations associated with the KCNQ1 gene are also believed to act mainly through a dominant-negative mechanism (the mutatnt form interferes with the function of the normal wild-type form through a 'poison pill' type mechanism) or loss of function mechanism. Even in the case of carriers of teh same mutaion, it is currently unknown why there are significant clinical phenotype variations in LQT1 patients. This question could be answered by increasing the number of patient genotypes studied. LQT1 patients expereince a majority of their cardiac events (62 p.c.) during exercise, and only 3 p.c. occur during rest or sleep. Of the patients who experienced cardiac events while swimming, 99 p.c. were LQT1. Auditory stimuli are rare and occur in only 2 p.c. of patients. However, both lethal and non-lethal events followthe same pattern.

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    Tytuł oryginału: Totally endoscopic bilateral internal thoracic artery bypass grafting in a young diabetic patient.
    Autorzy: Dogan Selami, Aybek Tayfun, Khan Mohammad Fawad, Neidhard Gerd, Auch-Schwelk Wolfgang, Moritz Anton, Wimmer-Greinecker Gerhard
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CS95-CS97, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The introduction of robotics into cardiosurgical practice in 1998 has enabled totally endoscopic closed chest procedures. Totally endoscopic grafting of the LAD (TECAB) is no longer an experimental procedure. Case report: We report on case with totally endoscopic bilateral thoracic artery bypass grafting to the left anterior descending and right coronary artery in a 36-year-old obese female diabetic patient using the daVinci surgical system. The patient, suffering from juvenile diabetes for 26 years, presented with stable angina (CCS class II). A coronary angiogram revealed 2-vessel disease with a long complex proximal lesion of the left anterior descending artery (LAD) (90 p.c.) and 80 p.c. stenosis of the proximal right coronary artery (RCA). Due to the condition of the proximal LAD (high risk PTCA with rather poor prognosis), the patient was referred for minimally invasive operative revascularization of the LAD and the RCA. After informed consent was obtained the patient underwent totally endoscopic double internal thoracic artery bypass revascularisation on the arrested heart using computer-enhanced telemanipulation technology. Conclusion: The feasibility and safety of successful closed chest, totally endoscopic double coronary bypass grafting with two internal thoracic arteries is demonstrated in this case. Preservation of a stable chest cavity and reduced risk for wound healing complications in diabetics with an excelent cosmetic result are the obvious advantages of the techniques described.

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