Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: MORACZEWSKA
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku

1/1

Tytuł oryginału: Structural determinants of cooperativity in acto-myosin interactions.
Autorzy: Moraczewska Joanna
Źródło: Acta Bioch. Pol. 2002: 49 (4) s.806-812, il., bibliogr. 811-812 - 38 Spotkanie Polskiego Towarzystwa Biochemicznego Wrocław 09. 2002
Sygnatura GBL: 303,116

Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Regulation of muscle contraction is a very cooperative process. The presence of tropomyosin on the thin filament is both necessary and sufficient for cooperativity to occur. Data recently obtained with various tropomyosin isoforms and mutants in the thin filament for cooperative protein interactions. Forming an end-to-end overlap between neighboring tropomyosin molecules is not necessary for the cooperativity of the thin filament activation. When direct contacts between tropomyosin molecules are disrupted, the conformational changes in the filament are most probably transmitted cooperatively through actin subunits, although the exact nature of these changes is not known. The function of tropomyosin ends, alternatively expressed in various isoforms, is to confer specific actin affinity. Tropomyosin's affinity or actin is directly related to the size of the apparent cooperative unit defined as the number of actin subunits turned into the active state by binding of one myosin head. Inner sequences of tropomyosin, particularly actin-binding periods 3 to 5, play crucial role in myosin-induced activation of the thin filament. A plausible mechanism of tropomyosin function in this process is that inner tropomyosin regions are either specifically recognized by myosin or they define the right actin conformation required for tropomyosin movement from its blocking position.

    stosując format: