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Tytuł oryginału: Lectins as markers for blood grouping.
Autorzy: Khan Fauzia, Khan Rizwan H., Sherwani Asma, Mohmood Sameena, Azfer Md. Asim
Źródło: Med. Sci. Monitor 2002: 8 (12) s.RA293-RA300, tab., bibliogr. 114 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • hematologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Lectins are unique proteins of varying biological importance. They are characterized by specific binding to carbohydrate residues, whether monosaccharides, disaccharides or polysaccharides. The sugar heads on the surface of the erythrocyte specify the different blood groups. Lectins, as an antigenic determinant of blood group, have come to be an important tool in the identification of different blood groups. A handful of lectins may be considered excellent reagents for anti-A, anti-B, anti-N etc, but the anti-A and anti-M are not yet regarded as compmercially suitable anitsera, Lectin from Vicia cracca, has been proved to be a good anti-A, lectin from Colichus biforus can be used as anti-A1, and lectin from Griffonia simplicifolia as anti0B. Lectin from Vicia graminea is said to be a good typing reagent as Anti-N. On the other hand, the lectins involved in polyagllutination are absolutely essential as the reagent of choice and these cannnot as yet be replaced by antibodies of any kind. Erythrocytes with exposed cryptantigens are significantly more sensitive to agglutination by certain lectins than by polyclonal antibodies. Peanut agglutinin (PNA), Polybrene, and Glycine max lectins are frequently used for the indetification of different cryptantigens. The application of lectins as an anti-B reagent has proven to be a useful as human polyclonal or mouse monoclonal antibodies. Besides their specificity, lectins are excellent reagents because of their lower cost and indigenous production. The importance of various lectins used as markers for blood grouping is discussed.

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