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Tytuł oryginału: Superoxide dismutase - applications and relevance to human diseases.
Autorzy: Noor Rana, Mittal Sonali, Iqbal Jawaid
Źródło: Med. Sci. Monitor 2002: 8 (9) s.RA210-RA215, bibliogr. 63 poz.
Sygnatura GBL: 313,278

Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Reactive oxygen species, such as superoxide radicals, are thought to underlie the pathogenesis of various diseases. Almost 3 to 10 p.c. of the oxygen utilized by tissues is converted to its reactive intermediates, which impair the functioning of cells and tissues. Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen. There are several classes of SOD that differ in their metal binding ability, distribution in different cell compartments, and sensitivity to various reagents. Among these, Cu, Zn superoxide dismutase (SOD1) is widely distributed and comprises 90 p.c. of the total SOD. This ubiquitous enzyme, which requires Cu and Zn for its activity, has great physiological significance and therpaeutic potential. The present review describes the role of SODs, especially Cu, Zn SOD, in several diseases, such as familal amyotrophic lateral sclerosis (FAL), Parkinson's disease, Alzheimer's disease, dengue fever, cancer, Down's syndrome, cataract, and several neurological disorders. Mutations in the SOD1 gene cause of familal form of amyotrophic lateral sclerosis. The mechanism by which mutant SOD1 causes the degeneration of motor neurons is not well understood. Transgenic mice expressing multiple copies of FALS-mutant SOD1s develop and ALS-like motor neuron disease. Vacuolar degeneration of mitochondria has been identified as the main pathological feature associated with motor neuron death and paralysis in several lines of FALS-SOD1 mice. Various observations and conclusions linking mutant SOD1 and FALS are discussed in this review in detail.

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