Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: MATZKU
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/1

Tytuł oryginału: Active vaccination after allogeneic bone marrow cell transplantation: a new option in the immunotherapy of cancer?
Autorzy: Z”ller Margot, Matzku Siegfried
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.197-224, bibliogr. 456 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The concept of immunotherapy of cancer was evoked more than a century ago by W. Coley. Yet it is only recently that the state of knowledge allows for molecularly defined therapeutic approaches and much effort will still be required to place immunotherapy beside of surgery, chemotherapy and radiation as a fourth option. In this review, we will focus chiefly on two aspects: active therapeutic vaccination, because it is our belief that this approach will provide a major breakthrough, and the potential efficacy of combining active vaccination with allogenic bone marrow cell transplantation. It was recently established in clinical trials that allogenic bone marrow cell transplantation does not require myeloablative conditioning. Non-myeloabaltive conditioning which avoids the high toxicity of the conventional approach, it is only kind which allows the recruitment of elderly patients and patients in poor health. Concerning active vaccination protocols, we will address the questions 1) what the targets (i.e. the Antigens) of immunotherapeutic approaches could be; 2) how to achieve an optimal confrontation of the immune system with these tumor-associated antigens; and 3) which response elements are needed for raising a therapeutically successful immune reaction against these antigens. Many question remain to be answered in the field of allogeneic bone marrow transplantation after non-myelablative conditioning to optimize the therapeutic setting for this, most likely, very powerfull tool of cancer therapy. We will briefy summarize current considerations to improve engraftment...

    stosując format: