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Tytuł oryginału: Epidemiologia zakażeń Clostridium difficile.
Tytuł angielski: Epidemiology of Clostridium difficile infection.
Autorzy: Szczęsny Adam, Martirosian Gayane
Źródło: Prz. Epidemiol. 2002: 56 (1) s.49-56, bibliogr. 53 poz., sum.
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Omówiono najważniejsze zagadnienia epidemiologii zakażeń wywołanych przez Clostridium difficile.

    Streszczenie angielskie: Pseudomembranous colitis (PMC), antibiotic-associated diarrhoea (AAD), and colitis (AAC) caused by Clostridium difficile are recognized as complications of antibiotic treatment (cephalosporins, penicillins, clindamycin and others). Two groups are particularly at risk: older and immunocompromised patients. In recent years Clostridium difficile has been recognized as a common nosocomial pathogen. To understand the epidemiology of the Clostridium difficile infection, many outbreaks have been investigated by various methods. In the paper we reviewed different methods of Clostridium difficile typing and discussed the epidemiology of Clostridium difficile-associated infections in light of recent publications.


    Tytuł oryginału: Characterization of Clostridium perfringens strains isolated from Polish patients with suspected antibiotic-associated diarrhea.
    Autorzy: Pituch Hanna, Braak Nicole van den, Belkum Alex van, Leeuwen Willem van, Obuch-Woszczatyński Piotr, Łuczak Mirosław, Verbrugh Henri, Meisel-Mikołajczyk Felicja, Martirosian Gayane
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR85-BR88, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of our research was to investigate the role of enterotoxin- producing anaerobic bacteria other than Clostridium difficile in the etiology of antibiotic-associated diarrhea. THis article presents data related to C. perfringens. Material/Methods: Stool samples taken from 158 patients with suspected antibiotic-associated diarrhea were specifically cultured for Clostridium difficile, Bacteroides fragilis and Clostridium perfringens. In order to associate the presence of virulence factors in the bacterial isolated thus collected with disease features, all strains were genetically and phenotypically analyzed for toxin production. All isolated C. perfringens strains were cultured in Ellner sporulation-promoting medium. Results: In 21 of the 158 patients (13 p.c.) C. perfringens could be cultivated from the fecal specimen. None of the strains produced eneterotoxin, and consequently the cpe gene was not detected by PCR in any of these strains. C. perfringens and C. difficile were cultivated from the same stool samples in 4 cases. Interestingly, in one case toxin A-negative/toxin B positive C. difficile and nonenterotoxigenic C. perfringens were co-cultured. After application of a heat shock (100řC at 30 min.) only two C. perfringens strains producing thermoresistant spores were detected. Pulsed field gel electrophoresis (PFGE) demonstrated genetic heterogenicity among the C. perfringens strains, suggesting that these bacteria were already presented upon hospital admission. Conclusion: It seems unlikely that nosocomial transfer has taken place. The relatively low incidence suggests that C. perfringens is not a major primary cause of antibiotic-associated diarrhea.

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