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Zapytanie: MARGREITER
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Tytuł oryginału: Experience with ATG short course high dose induction therapy in a series of 112 enteric drained pancreatic transplants.
Autorzy: Bonatti H., Berger N, Kafka R., Tabbi M. G., K”nigsrainer A., Margreiter R., Steurer W.
Źródło: Ann. Transplant. 2002: 7 (3) s.22-27, il., bibliogr. 13 poz.
Sygnatura GBL: 313,259

Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: New immunosuppressive protocols and advanced surgical technique resulted in a major improvement in the outcome of pancreatic transplantation. Patients and methods: 112 enteric drained whole pancreas transplants (PTx) performed at the Insbruck University Hospital between 3.1997 and 10.2001 were retrospectively analysed. Prophylactic immunosuppression consisted of FK506, MMF and steroids. A short course of high dose ATG induction was given additionally. Perioperative antimicrobial prophylaxis consisted of Amoxicllin/Clavulanic (32 PTx), Pipercillin/Tazobactam (68 PTx), quinolones (10 PTx) or macrolide (2 PTx). 64 patients additionally received fluconazole. Results: Actuarial patient, pancreas and kidney graft survival at one year were 96.4 p.c., 86.7 p.c. and 95.3 p.c., surgical complication rate was 28 p.c., rejection rate 40 p.c.. Eight grafts were lost due to intraabdominal infection, seven due to rejection. Median perioperative observation days (OD) were 29 (range 14-125), patients were on antibiotics for 68 p.c. of OD, and developed fever on 33 p.c. of OD. Incidence of CMV infection was 42 p.c. (bat only five patients developed CMV disease), HSV 24 p.c., intraabdominal infection 22 p.c., UTI 11 p.c., wound infection 9 p.c. and pneumonia: 5 p.c. Conclusion: ATG short course induction is well tolerated after enteric drained PTX. Infection represents a frequent and at least for IA sepsis serious complication after PTx with enteric drainage.

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