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Tytuł oryginału: An unfortunate epileptic.
Autorzy: Biswas Rakesh, Rao Ranga, Ghimere Gopal, Partha Praveen, Dalal Monica, Makaju Ramesh, Shetty K. J.
Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.239-241, bibliogr. 3 poz.
Sygnatura GBL: 313,612

Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Antiepileptic drugs rarely cause adverse reactions considering the frequency with which they are used in general practice. Current models of drug hypersensitivity center around the concept of drug bioactivation to reactive metasbolites that irreversibly modify cellular proteins. These modified proteined are believed to initiate (or serve as targets of) an autoimmune-like attack on specific drug-modified proteins in target organs (e.g., liver, skin) of susceptible individuals. Case report: We came across one person who devoted two relatively uncommon manifestations of two different antiepileptics. It may have been an autoimmune attack on drug-modified proteins in different target organs, which in our index case induced not only the skin and liver (which are commonly known to coincide) but also bone marrow. Conclusion: This forms a trio of complications due to antiepileptics, to the best of our knowledge possibly unreported to date in a single patient. Considering the immune basis for either reaction, it can be speculated that this patient has a susceptibility to develop an immune-mediated hypersensitivity to either of the antiepileptics but for each of them their target organ was different.

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