Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: LOUKAS
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Tytuł oryginału: Fibrinogen expression in atherosclerotic lesions in stable and unstable angina.
Tytuł polski: Ekspresja fibynogenu w blaszkach miażdżycowych naczyń wieńcowych u chorych ze stabilną lub niestabilną chorobą wieńcową.
Autorzy: Loukas Marios, Dąbrowski Marek, Wagner Teresa, Walczak Ewa, Witkowski Adam, Rużyłło Witold
Opracowanie edytorskie: Beręsewicz Andrzej (koment.), Kurzelewski Michał (koment.).
Źródło: Kardiol. Pol. 2002: 56 (2) s.155-162, il., tab., bibliogr. 24 poz. + bibliogr. 4 poz. - 22 Kongres Europejskiego Towarzystwa Kardiologicznego Amsterdam 2000 - Tekst równol. w jęz. pol.
Sygnatura GBL: 313,397

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background. During the last decade clinicians and researchers documented the relationship between high levels of fibrinogen and cardiovascular events. However, a number of questions arise concerning the histopathological characteristics of fibrinogen in human atherosclerotic plaques. Aim. To analyse atherosclerotic lesions obtained by directional coronary percutaneous atherectomy (DCA) and from post-mortem examinations of coronary arteries with the aim to localise the sites where fibrinogen is expressed in atherosclerotic plaques and to compare the findings between patietns with stable and unstable angina. Methods. 90 specimens (70 from DCA and 20 from post-mortem examinations) were collected from 52 men and 38 women (mean age 59.5 years). Each specimen was obtained immediately after tissue removal and stained with immunohistochemical methods using polyclonal antibodies (DAKO) for fibrinogen. Results. The plaques derived from the patietns with unstable angina showed a significantly higher number of expression sites than from the patietns with stable angina. The fibrinogen-rich area constituted from 8.2 p.c. to 80 p.c. of the total plaque area. Of the 53 specimens which were clustered close to the maximal value of 80 p.c., 37 were from unstable angina plaques and exhibited 76 ń 4 p.c. of fibrinogen rich area compared with 46 ń 5 p.c. of fibrinogen rich area in 16 specimens taken from patients with stable angina (p 0.005). Of the 37 specimens clustered close to the minimal values of the fibrinogen-rich area, 14 specimens were obtained from unstable patients...

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    Tytuł oryginału: Fibrinogen and smooth muscle cell detection in atherosclerotic plaques from stable and unstable angina - an immunohistochemical study.
    Autorzy: Loukas Marios, Dąbrowski Marek, Wagner Teresa, Walczak Ewa, Witkowski Andrzej, Rużyłło Witold
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR144-BR148, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: This study presents a systematic analysis of atherothrombotic lesions taken by percutaneous atherectomy and post mortem examination from coronary arteries, in order to identify: a) the topographic occurrence of fibrinogen and smooth muscle cells (SMCs), b) their independent expression in stable and unstable plaques, and c) their co-expression, which can provide a better understanding of the involvement of fibrinogen and SMCs in the development and progression of atherosclerotic plaques. Material/Methods: 120 specimens from atherosclerotic lesions were collected, using directional coronary atherectomy; 40 additional specimens were collected from postmortem examinations. All specimens were stained by immunohistochemical methods with monoclonal and polyclonal antibodies (DAKO) for fibrinogen and SMCs. Results: Fibrinogen appeared to be a component of all stable and unstable coronary atherosclerotic plaques, with a significant predominance in unstable angina. No significant difference was observed between SMC-stained areas in stable and unstable angina; however, a significant difference exists in co-expression of SMCs and fibrinogen between unstable and stable angina. Interestingly, the total number of SMCs at the first stages of formation of unstable plaques is less than in stable plaques. However, in a number of advanced coronary atherosclerotic plaques associated with unstable angina, we observed an increasingly progressive inflammatory cell activity, in which SMC areas were sifnigicantly increased...

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