Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: LOCATELLI
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Advances in the treatment of renal anaemia
Autorzy: Locatelli Francesco
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[147-160], il. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    2/2

    Tytuł oryginału: Allogenic stem cell transplantation following non-myeloablative conditioning regimens as adoptive immunotherapy in patients with hematological malignancies.
    Autorzy: Busca Alessandro, Bruno Benedetto, Boccadoro Mario, Locatelli Franco, Falda Michele
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA221-RA232, tab., bibliogr. 72 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: High-dose chemotherapy followed by allogenic stem cell transplantation has been extensively used for the treatment of patietns with hematological malignancies. Unfortunately, this life saving procedure is limited to a subset of patients who are in good medical condition due to the increased risk of regimen-related toxicity and graft-versus-host disease that occur with increasing age and poor performance status. On the other hand, it became apparent that the curative potential of transplantation was not solely due to the conditioning regimen but also to the graft-versus-leukemia effect mediated by alloreactive donor T cells. These observations led to the development of new transplant strategies using less intensive preparative regimens that would allows donor cell engraftment without the toxicity of myeloablative conditioning as a method of exploiting a graft-versus-malignancy effect in patients ineligible for conventional marrow grafts. Although follow-up is relatively short, preliminary results are encouraging and demonstrate the feasibility of non-myeloablative transplants in patients with heterogeneous diseases and disease status who received various preparative regiemns. Current challenges include defining the optiaml regimen to promote full donor engraftment and the malignancies susceptible to this approach. The present review summarizes the most recent results obtained in this attractive field.

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