Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: LIBEREK
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: TGF-á (transforming growth factor-á) in chronic inflammatory conditions - a new diagnostic and prognostic marker?
Autorzy: Marek Andrzej, Brodzicki Jacek, Liberek Anna, Korzon Maria
Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA145-RA151, il., bibliogr. 58 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: TGF-á is a cytokine with varied properties and pleiotropic activity. It is released in an inactive form. To exhibit its biological activity, it requires binding to extracellular matrix proteins and, after that, proteolytic elimination of LAP (Latent Associated Protein) and LTBP (Latent TGF-á Binding Protein). The process involves, among others, tissue transglutaminase, thrombin and plasmin. By stimulation of specific receptors, it influences transcription of some genes and translation of formed mRNA. Locally, it demonstrates proinflammatory properties whereas systemically, it has primarily a potent immunosuppressive effect. TGF-á, by affecting proliferation, differentiation and migration of cells, as well as stmulation of extracellular matrix protein production, plays an important role in tissue regeneration and remodeling, but also in fibrosis. TGF-á is also indispensable to maintain immune homeostasis of the organism. Reduced TGF-á activity is considered to be responsible for development of autoimmune disorders in the course of several pathologic conditions. This cytokine plays an important role in the pathogenesis of chronic inflammatory processes taking place, among others, in inflammatory bowel diseases (IBD) and chronic hepatitis B and C. The paper presents a review of literature concerning diagnostic and prognostic value of TGF-á level determinations in blood and tissue bioptates of patients with chronic non-specific enteritis and chronic hepatitis B and C.

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    Tytuł oryginału: Cytomegalovirus disease in neonates and infants - clinical presentation, diagnostic and therapeutic problems - own experience.
    Autorzy: Liberek Anna, Rytlewska Marlena, Szlagatys-Sidorkiewicz Agnieszka, Bako Wanda, Łuczak Grażyna, Sikorska-Wiśniewska Grażyna, Korzonut. Maria
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR815-CR820, il., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to present diagnostic problems, different clinical presentations and results of treatment of cytomegalovirus infections in neonates and infants. Material and methods: The study was carried out in a group of 31 children from 10 days to 12 months of age (17 boys, 14 girls). The diagnosis was based on serological investigations (presence of specific IgM antibodies and/or increasing titer of IgG antibodies), presence of intermediate or early CMV antigen in peripheral blood leukocytes or positive blood or urine PCR results. The treatment of 25 cases involved intravenous administration of gancyclovir at 5-7 mg/kg daily doses for 14-21 days. In 1 case, hyperimmunized anti-CMV serum - Cytotect was used. Results: The most common clincal symptoms were jaundice, hepato- and splenomegaly. Clinical investigations demonstrated increased aminotransferase activity and the signs of cholestasis. Other frequent findings included anemia, leukocytosis with atypical lymphocyte forms present, as well as thrombocytopenia. In majority treated patients, rapid regression of the clinical symptoms and normalization of transaminases activity was observed. Good outcome of the therapy was confirmed by immunological investigations. The effecst of the therapy were similar irrespective of the dosee and duration of gancyclovir treatment. The tolerance of the drug was good - no indications for discontinuation of the treatment were observed in any of the patients. Conclusions: The clinical presentations of cytomegalovirus disease in infants are varied, the diagnosis...

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