Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
LASKOSZ
Liczba odnalezionych rekordów:
1
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Tytuł oryginału:
A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time.
Autorzy:
Hliniak
A.,
Gwiazdowska
B.,
Szutkowski
Z.,
Kraszewska
E.,
Kukolowicz
P.,
Jarząbski
A.,
Sochacka
B.,
Mazurkiewicz
M.,
Paprota
K.,
Oliskiewicz
W.,
Zadrożna
O.,
Milecki
P.,
Kubiak
M.,
Czopkiewicz
L.,
Jagas
M.,
Góźdź
S.,
Wieczorek
A.,
Woytowicz
A.,
Cisowska
B.,
Magdziarz
H.,
Nowakowski
S.,
Kośniewski
W.,
Laskosz
I.,
Serafin
A.,
Gradoń
E.
Źródło:
Radiother. Oncol. 2002: 62 (1) s.1-10, il., tab., bibliogr. 13 poz.
Sygnatura GBL:
312,846
Hasła klasyfikacyjne GBL:
onkologia
otorynolaryngologia
Typ dokumentu:
praca kliniczna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Background and purpose: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. Materials and methods: Patietns with ó 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, NO, MO, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thrusday). A total of 395 patients were included from 05.1995 to 12.1998. Results. Early toxicity: At the end of radiotherapy patietns treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P = 0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P = 0.001) were similar in the two groups. Locoregional control: comparison between CF and AF showed no difference in terms of loco-regional control (P = 0.37). Conclusions: The improvement in AF in terms of loco-regional control is estimated to be 3-5 p.c. in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.
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