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Tytuł oryginału: Clinico-pathological aspects of radiofrequency ablation in the treatment of benign thyroid tumors.
Autorzy: Nawrot Ireneusz, Grzesiuk Wiesław, Kluge Przemysław, Wojtaszek Mikołaj, Kyzioł-Otto Grażyna, Otto Maciej, Buczyńska-Chyl Jolanta, Karwacki Jerzy, Jędrasik Maciej, Chudziński Witold, Pietrasik Kamil, Dębińska-Szymańska Tamara, Jaworski Maciej, Bar-Andziak Ewa, Tołłoczko Tadeusz, Woźniewicz Bogdan M., Szmidt Jacek
Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.97-101, tab., bibliogr. 12 poz.
Sygnatura GBL: 313,395

Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the study was to standardize a dependable method, which would be used to differentiate thyroid carcinoma in fine-needle biopsies and to adapt radiofrequency ablation techniques to safety treat benign thyroid tumors. Fine-needle aspiration biopsies, taken pre- and intraoperatively were assessed cytologically and histologically. Immunochemical markers (PCNA, Ki67 and AgNOR) were used to differentiate between carcinoma and benign folicular adenomas. Apoptosis was studied in benign tumors using TUNEL, Bcl-2, CD95 and Bax immunoassays. Ablation was performed intraoperatively on thyroid tissue fragments ranging in size from 1,3 to 2,2 cm, mean 1,7 ń 0,5 prepared for resection with full blood perfusion of the gland. AgNOR silver staining was used to assess the number of active nucleoi "NORs". Benign proliferation showed a number of 1-2 nuceloli, in adenomas 4-6 nucleoli and 8 nucleoli in malignancies. PCNA showed highest specificity where 80 p.c. of cancerous cells had positive results. The Ki67 marker in primary cancer showed no staining and stained positive in 50 p.c. of metastatic cancer. Apoptosis was also not increased in the case of adenomas. In the 58 patients undergoing the procedure we noted in 4 patients (6,1 p.c.) temporary laryngeal nerve paralysis, in 2 (3 p.c.) cases minute bleeding after needle arm retraction. To conclude: 1) the suggested assay panel is able to discriminate between follicular carcinoma and adenoma, 2) radiofrequency ablation can be an alternative to surgical methods in neutral nodular goiter, 3) necrosis zone of the ablated thyroid lesion is closely correlated to the used ablation parameters.

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