Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: KYRTOPOULOS
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Tytuł oryginału: Assessment of biomarkers of the immunomodulatory effects of asbestos in asbestos cement plant workers.
Autorzy: Tulinska Jana, Dusinska Maria, Jahnova Eva, Liskova Aurelia, Kuricova Miroslava, Weissova Silvia, Horvathova Mira, Wsolova Ladislava, Machata Miroslaw, Kyrtopoulos Soterios A., Fuortes Laurence
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.95-101, il. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Immune parameters were examined in 61 workers exposed to asbestos fibres for an average of 23 years as well as in 46 town and 21 in-factory unexposed controls. Humoral immunity was evaluated by levels of immunoglobulins, concentrations of interleukins and soluble adhesion molecules. Cellular immunity was determined by phenotypic analysis of peripheral blood leukocytes (CD3, HLA DR, CD4, CD8, CD16+56, CD19), expression of adhesion molecules on leukocytes and activation markers on eosinophils. Immune function assays - proliferative response of lymphocytes and phagocytic activity of leukocytes were evaluated in exposed and unexposed populations. Using multifactorial analysis of variance we found significantly increased levels of immunoglobulin E, concentrations of IL-6 and soluble adhesion molecule ICAM-1 in asbestos exposed workers. Expression of adhesion molecule CD62L (L-selectin) on monocytes and granulocytes was significantly higher in explosed workers. Moreover CD69 and CD66b markers on eosinophils were significantly increased among people exposed to asbestos. Immune function assays showed a significant decrease in proliferative response of lymphocytes stimulated by T-cell mitogen PHA in the exposed group. Proliferation of lymphocytes stimulated through T-cell receptors, T-dependent B-cell response an memory cell function did not differ between exposed workers and controls. Spearman correlation analysis revealed decreasing proliferative response of T and B-lymphocytes in the exposed population with ...

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    Tytuł oryginału: Biomarkers of genotoxicity of urban air pollution: achievements, problems, prospects.
    Autorzy: Kyrtopoulos Soterios A., Georgiadis Panagiotis
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.215-228, il., tab., bibliogr. 31 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska

    Typ dokumentu:
  • praca związana ze zjazdem

    Streszczenie angielskie: Recent evidence suggests that exposure to urban air pollution may result in increased risk of lung cancer. Extrapolation from occupational exposure and risk data suggests that, among potential carcinogens present in polluted urban air, polycyclic aromatic hydrocarbons (PAH's) may make a major contribution to such an effect. The use of biomarkers of genotoxicity in population studies may help to reduce uncertainty involved in the risk of cancer associated with relatively low air pollution levels. While increases in biomarkers of exposure to urban air PAH's, as well as biomarkers of early genetic effects, have been detected in subject exposed to relatively high levels of air pollution, biomarker studies in populations exposed to ambient PAH concentrations below approx. 20 ng/m**3have not demonstrated clear effect, possibly because of the existence of multiple sources and routes of human exposure. Results from a recent molecular epidemiology study designed to investigate biomarker variation in subjects exposed to low to moderate levels of urban air pollution (the AULIS project) have also failed to show any consistent effects of ambient air PAHs. The most important parameter found in this study to influence the levels of bulky DNA adducts in blood lymphocytes was exposure to environmental tobacco smoke (ETS), wwhile at very low levels of ETS exposure an effect of consumption of roasted meat could be detected. Strong interactions between these exposures and genetic variation in phase I and phase II xenobiotic metabolism ...

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